triple negative breast cancer

[npj Breast Cancer] Investigators demonstrated that endoplasmic reticulum stress could decrease androgen receptor mRNA and protein levels via PERK/eIF2α/ATF4 signaling in luminal androgen receptor TNBC and prostate cancer.

[Molecular Cancer Research] Using MCF10A as a model of non-tumorigenic epithelial breast cells, scientists found that silencing KDM6A promoted cell migration and transformation demonstrated by the formation of tumor-like acini in three-dimensional culture.

[Cancer] Researchers review the role of tumor-infiltrating Tregs in tumor progression and metabolic reprogramming of the tumor microenvironment.

[Cancer Immunology Research] Investigators combined intratumoral STimulator of INterferon Genes (STING) agonist therapy with systemically injected extended half-life IL2 and anti–PD-1 checkpoint blockade to drive innate and adaptive antitumor immunity in models of triple-negative breast cancer.

[Molecular Therapy Oncolytics] Scientists found that PBX3-activated DLG1-AS1 could promote the proliferation, invasion and migration of TNBC cells by sponging miR-16-5p and elevating JARID2 expression.

[Frontiers in Immunology] The stemness of OAcGD2+ cells isolated by sorting and the effects of mAb8B6 were assessed by cancer stem cell growth and mammosphere formation in vitro and tumor growth in vivo using patient-derived xenograft models.