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Point-of-Care Diagnostic Tests for Tuberculosis Disease

[Science Translational Medicine] Scientists evaluate current diagnostic assays endorsed by the World Health Organization and identify the gaps between existing conventional tests and the ideal point-of-care test for tuberculosis disease.

Chemical–Genetic Interaction Mapping Links Carbon Metabolism and Cell Wall Structure to Tuberculosis Drug Efficacy

[Proceedings of the National Academy of Sciences of the United States of America] The authors utilized conditional Mycobacterium tuberculosis (Mtb) knockdown mutants of essential genes as an experimentally tractable surrogate for drug treatment and probed the relationship between Mtb carbon metabolism and chemical-genetic interactions

Mice Infected with Mycobacterium tuberculosis Are Resistant to Acute Disease Caused by Secondary Infection with SARS-CoV-2

[PLoS Pathogens] In both model systems, Mycobacterium tuberculosis (Mtb)-infected mice were resistant to the pathological consequences of secondary SARS-CoV-2 infection, and SARS-CoV-2 infection did not affect Mtb burdens.

Platelets Accumulate in Lung Lesions of Tuberculosis Patients and Inhibit T Cell Responses and Mycobacterium tuberculosis Replication in Macrophages

[European Journal of Immunology] In vitro activated platelets inhibited Bacillus Calmette-Guerin-induced T lymphocyte proliferation and IFN-γ production.

Surveying the Epigenetic Landscape of Tuberculosis in Alveolar Macrophages

[Infection and Immunity] Investigators compare the fundamental differences between alveolar macrophages and circulating monocyte-derived macrophages in the context of tuberculosis and summarize the recent advances in elucidating the epigenomes of these cells.

Surge of HIV, Tuberculosis and COVID Feared amid War in Ukraine

[NatureNews] Adding to the brutal, immediate effects of Russia’s invasion, the Ukrainian people are facing an onslaught of infectious diseases. Some threats — such as the spread of COVID-19 — are immediate, as people huddle in basements, subway stations and temporary shelters to protect themselves from bombardments.