Single-Cell Immune Profiling Reveals Functional Diversity of T Cells in Tuberculous Pleural Effusion

Using single-cell transcriptomics and T cell receptor sequencing, scientists analyzed mononuclear cell populations in paired pleural fluid and peripheral blood of tuberculous pleural effusion patients.
[Journal of Experimental Medicine]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Mycobacterial Skin Infection

Scientists review the most recent evidences concerning mycobacterial skin infections, limiting the period of literature research to 2020–2021.
[Current Opinion in infectious Diseases]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Lung Epithelial Cells Interact with Immune Cells and Bacteria to Shape the Microenvironment in Tuberculosis

Scientists discuss the interplay between lung endothelial cell, immune cells and Mycobacterium tuberculosis (Mtb) and argue that modeling these interactions is of key importance to unravel early events during Mtb infection.
[Thorax]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

CD4 and CD8 Co-Receptors Modulate Functional Avidity of CD1b-Restricted T Cells

Scientists showed CD1b-mycolipid tetramers revealed a hierarchy in which circulating T cells expressing CD4 or CD8 co-receptor stain with a higher tetramer mean fluorescence intensity than CD4-CD8 T cells.
[Nature Communications]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Myeloid-Derived Suppressor Cells Mediate T Cell Dysfunction in Nonhuman Primate TB Granulomas

Scientists performed an in-depth study of myeloid-derived suppressor cells during latent tuberculosis (TB) infection and active TB using the nonhuman primate (NHP) model of pulmonary TB.
[mBio]
[zotpress userid=” items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

A Combination of Circulating microRNA-375-3p and Chemokines CCL11, CXCL12, and G-CSF Differentiate Crohn’s Disease and Intestinal Tuberculosis

miR-375-3p, the pulmonary TB specific marker was found in higher amount in the plasma of intestinal tuberculosis patients than Crohn’s disease while reverse expression was observed in the ileocaecal/terminal ileal tissues of the same patients.
[Scientific Reports]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

A Single Dose, BCG-Adjuvanted COVID-19 Vaccine Provides Sterilising Immunity against SARS-CoV-2 Infection

Scientists exploited the immunostimulatory properties of bacille Calmette-Guérin, the existing tuberculosis vaccine, to deliver a vaccination regimen with potent SARS-CoV-2-specific protective immunity.
[NPJ Vaccines]
[zotpress userid=” items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Single-Cell Transcriptomic Profiles Reveal Changes Associated with BCG-Induced Trained Immunity and Protective Effects in Circulating Monocytes

To better understand Bacillus Calmette-Guérin (BCG)-induced immune reprogramming, investigators performed single-cell transcriptomic measurements before and after BCG vaccination using secondary immune stimulation with bacterial lipopolysaccharide.
[Cell Reports]
[zotpress userid=” items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Mycobacterium tuberculosis Exploits Focal Adhesion Kinase to Induce Necrotic Cell Death and Inhibit Reactive Oxygen Species Production

The authors demonstrated that Mycobacterium tuberculosis infection triggered a time-dependent reduction in the expression of focal adhesion kinase in human macrophages.
[Frontiers in Imm]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Monoclonal Antibodies from Humans with Mycobacterium tuberculosis Exposure or Latent Infection Recognize Distinct Arabinomannan Epitopes

The authors generated human IgG mAbs to AM/LAM from B cells of two asymptomatic individuals exposed to or latently infected with M. tuberculosis.
[Communications Biology]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Identification of Covalent Inhibitors That Disrupt M. tuberculosis Growth by Targeting Multiple Serine Hydrolases Involved in Lipid Metabolism

Researchers screened a library of small molecules containing serine-reactive electrophiles and identified narrow-spectrum inhibitors of M. tuberculosis growth.
[Cell Chemical Biology]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share
Share