Relationship of SARS-CoV-2-Specific CD4 Response to COVID-19 Severity and Impact of HIV-1 and Tuberculosis Co-Infection

Investigators assessed the magnitude, function and phenotype of SARS-CoV-2-specific CD4 T cells in 95 hospitalized COVID-19 patients and 38 non-COVID-19 patients, using flow cytometry.
[Journal of Clinical Investigation]
Riou, C., Bruyn, E. D., Stek, C., Daroowala, R., Goliath, R. T., Abrahams, F., Said-Hartley, Q., Allwood, B. W., Hsiao, N.-Y., Wilkinson, K. A., Arlehamn, C. S. L., Sette, A., Wasserman, S., & Wilkinson, R. J. (2021). Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and Tuberculosis co-infection. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI149125 Cite
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Differences in Host Immune Populations between Rhesus Macaques and Cynomolgus Macaque Subspecies in Relation to Susceptibility to Mycobacterium tuberculosis Infection

Researchers characterized the constituent monocyte and lymphocyte populations between macaque species, and profile other major immune cell subsets including: CD4+ and CD8+ T cells, NK cells, B cells, monocyte subsets and myeloid dendritic cells.
[Scientific Reports]
Sibley, L., Daykin-Pont, O., Sarfas, C., Pascoe, J., White, A. D., & Sharpe, S. (2021). Differences in host immune populations between rhesus macaques and cynomolgus macaque subspecies in relation to susceptibility to Mycobacterium tuberculosis infection. Scientific Reports, 11(1), 8810. https://doi.org/10.1038/s41598-021-87872-x Cite
Full Article
Bookmark

No account yet? Register

0
Share

Overexpression of microRNA-340-5p Ameliorates Inflammatory Response and Intracellular Survival of Mycobacterium Tuberculosis in Alveolar Type II Cells

Scientists estimated the role of miR-340-5p in Mycobacterium tuberculosis-infected alveolar type II cells.
[infection and Drug Resistance]
Zhang, B., Li, H., Zhang, J., Hang, Y., & Xu, Y. (2021, April 21). <p>Overexpression of microRNA-340-5p Ameliorates Inflammatory Response and Intracellular Survival of <em>Mycobacterium Tuberculosis</em> in Alveolar Type II Cells</p>. Infection and Drug Resistance. https://doi.org/10.2147/IDR.S291867 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Tissue Resident-Like CD+ T Cells Secreting IL-17 Control Mycobacteria Tuberculosis in the Human Lung

Mycobacterium tuberculosis-specific CD4 T cells producing TNF-α, IL-2 and IL-17 were highly expanded in the lung compared to matched blood samples, in which IL-17+ cells were largely absent.
[Journal of Clinical Investigation]
Ogongo, P., Tezera, L. B., Ardain, A., Nhamoyebonde, S., Ramsuran, D., Singh, A., Ngoepe, A., Karim, F., Naidoo, T., Khan, K., Dullabh, K. J., Fehlings, M., Lee, B. H., Nardin, A., Arlehamn, C. S. L., Sette, A., Behar, S. M., Steyn, A. J. C., Madansein, R., … Leslie, A. (2021). Tissue resident-like CD4+ T cells secreting IL-17 control Mycobacteria tuberculosis in the human lung. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI142014 Cite
AbstractFull Article
Bookmark

No account yet? Register

0
Share

Resistance of Mycobacterium tuberculosis to Indole 4-Carboxamides Occurs through Alterations in Drug Metabolism and Tryptophan Biosynthesis

Tryptophan biosynthesis represents an important potential drug target for new anti-TB drugs. Scientists identified a series of indole-4-carboxamides with potent antitubercular activity.
[Cell Chemical Biology]
Libardo, M. D. J., Duncombe, C. J., Green, S. R., Wyatt, P. G., Thompson, S., Ray, P. C., Ioerger, T. R., Oh, S., Goodwin, M. B., Boshoff, H. I. M., & Barry, C. E. (2021). Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis. Cell Chemical Biology, 0(0). https://doi.org/10.1016/j.chembiol.2021.02.023 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

A Non-canonical Type 2 Immune Response Coordinates Tuberculous Granuloma Formation and Epithelialization

Researchers found that type 2 immune signaling, mediated via stat6, was absolutely required for epithelialization and granuloma formation.
[Cell]
Cronan, M. R., Hughes, E. J., Brewer, W. J., Viswanathan, G., Hunt, E. G., Singh, B., Mehra, S., Oehlers, S. H., Gregory, S. G., Kaushal, D., & Tobin, D. M. (2021). A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.02.046 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

TGFβ Restricts Expansion, Survival, and Function of T Cells within the Tuberculous Granuloma

In a murine infection model, scientists observed that IFNɣ production by Mtb-specific CD4 T cells was rapidly extinguished within the granuloma but not within unaffected lung regions, suggesting localized immunosuppression.
[Cell Host & Microbe]
Gern, B. H., Adams, K. N., Plumlee, C. R., Stoltzfus, C. R., Shehata, L., Moguche, A. O., Busman-Sahay, K., Hansen, S. G., Axthelm, M. K., Picker, L. J., Estes, J. D., Urdahl, K. B., & Gerner, M. Y. (2021). TGFβ restricts expansion, survival, and function of T cells within the tuberculous granuloma. Cell Host & Microbe, 0(0). https://doi.org/10.1016/j.chom.2021.02.005 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

+1
Share

CD38+ CD27 TNF-α+ on Mtb-Specific CD4+ T Is a Robust Biomarker for Tuberculosis Diagnosis

Scientists queried the diagnostic ability of phenotypic markers on Mycobacterium tuberculosis-specific cytokine-producing immune cell subsets for identifying active tuberculosis.
[Clinical Infectious Diseases]
Acharya, M. P., Pradeep, S. P., Murthy, V. S., Chikkannaiah, P., Kambar, V., Narayanashetty, S., Burugina Nagaraja, S., Niveditha, D., Yoganand, R., & Satchidanandam, V. (2021). CD38 +CD27 –TNF-α + on Mtb-specific CD4 + T is a robust biomarker for tuberculosis diagnosis. Clinical Infectious Diseases, ciab144. https://doi.org/10.1093/cid/ciab144 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Three-Dimensional Low Shear Culture of Mycobacterium bovis BCG Induces Biofilm Formation and Antimicrobial Drug Tolerance

Researchers adapted a three-dimensional Rotary Cell Culture System to model M. bovis BCG biofilm growth in low-shear detergent-free liquid suspension.
[npj Biofilms and Microbiomes]
Three-dimensional low shear culture of Mycobacterium bovis BCG induces biofilm formation and antimicrobial drug tolerance | npj Biofilms and Microbiomes. (n.d.). Retrieved February 2, 2021, from https://www.nature.com/articles/s41522-021-00186-8 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Early Innate and Adaptive Immune Perturbations Determine Long-Term Severity of Chronic Virus and Mycobacterium tuberculosis Coinfection

Researchers developed a coordinated system of chronic virus and Mycobacterium tuberculosis (Mtb) infection that induced central clinical manifestations of coinfection, including increased Mtb burden, extra-pulmonary dissemination, and heightened mortality.
[Immunity]
Xu, W., Snell, L. M., Guo, M., Boukhaled, G., Macleod, B. L., Li, M., Tullius, M. V., Guidos, C. J., Tsao, M.-S., Divangahi, M., Horwitz, M. A., Liu, J., & Brooks, D. G. (2021). Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2021.01.003 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

0
Share

Human Antibodies Targeting a Mycobacterium Transporter Protein Mediate Protection against Tuberculosis

Investigators generated monoclonal antibodies from memory B cells of one patient to investigate the B cell responses during active infection.
[Nature Communications]
Watson, A., Li, H., Ma, B., Weiss, R., Bendayan, D., Abramovitz, L., Ben-Shalom, N., Mor, M., Pinko, E., Bar Oz, M., Wang, Z., Du, F., Lu, Y., Rybniker, J., Dahan, R., Huang, H., Barkan, D., Xiang, Y., Javid, B., & Freund, N. T. (2021). Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis. Nature Communications, 12(1), 602. https://doi.org/10.1038/s41467-021-20930-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share