Monoclonal Antibodies from Humans with Mycobacterium tuberculosis Exposure or Latent Infection Recognize Distinct Arabinomannan Epitopes

The authors generated human IgG mAbs to AM/LAM from B cells of two asymptomatic individuals exposed to or latently infected with M. tuberculosis.
[Communications Biology]
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Identification of Covalent Inhibitors That Disrupt M. tuberculosis Growth by Targeting Multiple Serine Hydrolases Involved in Lipid Metabolism

Researchers screened a library of small molecules containing serine-reactive electrophiles and identified narrow-spectrum inhibitors of M. tuberculosis growth.
[Cell Chemical Biology]
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Identification of Cell Wall Synthesis Inhibitors Active against Mycobacterium tuberculosis by Competitive Activity-Based Protein Profiling

Researchers studied the effects of 1,2,3-triazole ureas on Mycobacterium tuberculosis. After screening ∼200 compounds, they focused on 4 compounds that formed a structure-activity series.
[Cell Chemical Biology]
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CD4 T Cell Help Prevents CD8 T Cell Exhaustion and Promotes Control of Mycobacterium tuberculosis Infection

Using two independent models, scientists showed that CD4 T cell help enhanced CD8 effector functions and prevented CD8 T cell exhaustion.
[Cell Reports]
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Pulmonary Histoplasmosis

Scientists review clinical manifestations, radiological findings and treatment options according to the clinical form, as well as different diagnosis tools and new laboratory tests that have been recently developed and validated and are becoming widely available.
[Mycopathologia]
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Interleukin-27 Promotes Autophagy in Human Serum-Induced Primary Macrophages via an mTOR- and LC3-Independent Pathway

Researchers investigated the impact of IL-27 in both autophagy induction and HIV-1 infection in macrophages.
[Scientific Reports]
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Macrophage and Neutrophil Death Programs Differentially Confer Resistance to Tuberculosis

Researchers defined crucial in vivo functions of the death receptor-mediated and BCL-2-regulated apoptosis pathways in mediating protection against tuberculosis by eliminating distinct populations of infected macrophages and neutrophils and priming T cell responses.
[Immunity]
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An Immunoinformatics Approach to Design a Multi-Epitope Vaccine against Mycobacterium tuberculosis Exploiting Secreted Exosome Proteins

An in-silico approach has been adopted to construct a multi-epitope vaccine from selected immunogenic extracellular vesicle proteins to elicit a cellular as well as a humoral immune response.
[Scientific Reports]
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PGE2 Displays Immunosuppressive Effects during Human Active Tuberculosis

Researchers demonstrated that prostaglandin E2 (PGE2) exerted a potent immunosuppressive action during the immune response of the human host against Mycobacterium tuberculosis infection.
[Scientific Reports]
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Inherited PD-1 Deficiency Underlies Tuberculosis and Autoimmunity in a Child

Investigators studied a patient with inherited PD-1 deficiency and tuberculosis who died of pulmonary autoimmunity. The patient’s leukocytes did not express PD-1 or respond to PD-1-mediated suppression.
[Nature Medicine]
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Praedicare Inc. Receives Grant to Evaluate Potential New Drug Regimens for Tuberculosis

Praedicare Inc., announced it has been awarded a two-year, $2.8 million grant by the Bill & Melinda Gates Foundation to evaluate novel Tuberculosis (TB) drug regimens using Praedicare’s in vitro hollow fiber model of TB in identifying potential new drug regimens that shorten treatment times for the disease.
[Praedicare Inc. (BusinessWire, Inc.)]
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