tuberculosis

[Communications Biology] The authors generated human IgG mAbs to AM/LAM from B cells of two asymptomatic individuals exposed to or latently infected with M. tuberculosis.

[Cell Chemical Biology] Researchers studied the effects of 1,2,3-triazole ureas on Mycobacterium tuberculosis. After screening ∼200 compounds, they focused on 4 compounds that formed a structure-activity series.

[Cell Chemical Biology] Researchers screened a library of small molecules containing serine-reactive electrophiles and identified narrow-spectrum inhibitors of M. tuberculosis growth.

[Cell Reports] Using two independent models, scientists showed that CD4 T cell help enhanced CD8 effector functions and prevented CD8 T cell exhaustion.

[Mycopathologia] Scientists review clinical manifestations, radiological findings and treatment options according to the clinical form, as well as different diagnosis tools and new laboratory tests that have been recently developed and validated and are becoming widely available.

[Scientific Reports] Researchers investigated the impact of IL-27 in both autophagy induction and HIV-1 infection in macrophages.