Tag results:
type-
Dermal Cell News
Adaptive Translational Reprogramming of Metabolism Limits the Response to Targeted Therapy in BRAFV600 Melanoma
[Nature Communications] Researchers examined how targeted therapy reprograms metabolism in BRAF-mutant melanoma cells using a genome-wide RNA interference screen and global gene expression profiling.
Cell Therapy News
Rabies Virus Glycoprotein-Mediated Transportation and T Cell Infiltration to Brain Tumor by Magnetoelectric Gold Yarnballs
[ACS Nano] A rabies virus glycoprotein (RVG)-camouflaged gold yarnball that could boost the targeting efficiency at a brain tumor via dual hierarchy- and RVG-mediated spinal cord transportation, facilitating the decrease of tumor heterogeneity for T cell infiltration, was developed.
Neural Cell News
Novel Dopamine Receptor 3 Antagonists Inhibit the Growth of Primary and Temozolomide Resistant Glioblastoma Cells
[PLoS One] To improve treatment of glioblastoma, including those resistant to temozolomide , we explored the potential of targeting dopamine receptor signaling.
Neural Cell News
SynNotch-CAR T Cells Overcome Challenges of Specificity, Heterogeneity, and Persistence in Treating Glioblastoma
[Science Translational Medicine] developed synthetic notch (synNotch)–CAR T cells targeting solid tumor antigens and used them to treat mouse models of mesothelioma, ovarian cancer, and glioblastoma.
Neural Cell News
Optogenetic Pacing of Medial Septum Parvalbumin-Positive Cells Disrupts Temporal but Not Spatial Firing in Grid Cells
[Science Advances] we show that optogenetic activation of parvalbumin-positive cells in the medial septal area enabled selective pacing of local field potential oscillations in medial entorhinal cortex.
Neural Cell News
Neuromodulator Release in Neurons Requires Two Functionally Redundant Calcium Sensors
[Proceedings of the National Academy of Sciences of the United States of America] we show that in mouse hippocampal neurons, dense core vesicles fusion is strongly and equally reduced in synaptotagmin-1 (Syt1)- or Syt7-deficient neurons, but combined Syt1/Syt7 deficiency did not reduce fusion further.