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Adaptive Translational Reprogramming of Metabolism Limits the Response to Targeted Therapy in BRAFV600 Melanoma

[Nature Communications] Researchers examined how targeted therapy reprograms metabolism in BRAF-mutant melanoma cells using a genome-wide RNA interference screen and global gene expression profiling.

Rabies Virus Glycoprotein-Mediated Transportation and T Cell Infiltration to Brain Tumor by Magnetoelectric Gold Yarnballs

[ACS Nano] A rabies virus glycoprotein (RVG)-camouflaged gold yarnball that could boost the targeting efficiency at a brain tumor via dual hierarchy- and RVG-mediated spinal cord transportation, facilitating the decrease of tumor heterogeneity for T cell infiltration, was developed.

Novel Dopamine Receptor 3 Antagonists Inhibit the Growth of Primary and Temozolomide Resistant Glioblastoma Cells

[PLoS One] To improve treatment of glioblastoma, including those resistant to temozolomide , we explored the potential of targeting dopamine receptor signaling.

SynNotch-CAR T Cells Overcome Challenges of Specificity, Heterogeneity, and Persistence in Treating Glioblastoma

[Science Translational Medicine] developed synthetic notch (synNotch)–CAR T cells targeting solid tumor antigens and used them to treat mouse models of mesothelioma, ovarian cancer, and glioblastoma.

Optogenetic Pacing of Medial Septum Parvalbumin-Positive Cells Disrupts Temporal but Not Spatial Firing in Grid Cells

[Science Advances] we show that optogenetic activation of parvalbumin-positive cells in the medial septal area enabled selective pacing of local field potential oscillations in medial entorhinal cortex.

Neuromodulator Release in Neurons Requires Two Functionally Redundant Calcium Sensors

[Proceedings of the National Academy of Sciences of the United States of America] we show that in mouse hippocampal neurons, dense core vesicles fusion is strongly and equally reduced in synaptotagmin-1 (Syt1)- or Syt7-deficient neurons, but combined Syt1/Syt7 deficiency did not reduce fusion further.

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