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Cell Therapy News
Engineering Magnetotactic Bacteria MVs to Synergize Chemotherapy, Ferroptosis and Immunotherapy for Augmented Antitumor Therapy
[Nanoscale Horizons] Inspired by the development of synergistic therapeutic strategies, scientists proposed a novel nanovaccine-based platform to achieve chemotherapy, ferroptosis therapy, and immunotherapy simultaneously.
Cell Therapy News
Lipid Nanoparticle mRNA Systems Containing High Levels of Sphingomyelin Engender Enhanced Protein Expression in Hepatic and Extra-Hepatic Tissues
[Molecular Therapy-Methods & Clinical Development] The authors investigated the properties of lipid nanoparticles-mRNA systems prepared with high levels of “helper” lipids such as distearoyl phosphatidylcholine or egg sphingomyelin.
Cell Therapy News
Decellularized Periosteum Promotes Guided Bone Regeneration via Manipulation of Macrophage Polarization
[Biotechnology Journal] Researchers fabricated decellularized periosteum (DP) and investigate its immunomodulatory properties in guided bone regeneration. DP was successfully fabricated from periosteum from the mini-pig cranium.
Cell Therapy News
Chimeric Antigen Receptor (CAR) T Cells for the Treatment of a Kidney Transplant Patient with Post-transplant Lymphoproliferative Disorder (PTLD)
[Human Vaccines & Immunotherapeutics] Investigators showed that even with the background of prolonged immunosuppression for solid organ transplant, it is possible to generate autologous CAR-T products capable of expansion and persistence in vivo, without evidence of excess T cell exhaustion.
Muscle Cell News
TMEM11 Regulates Cardiomyocyte Proliferation and Cardiac Repair via METTL1-Mediated m7G Methylation of ATF5 mRNA
[Cell Death & Differentiation] Investigators detected that the mitochondrial transmembrane protein 11 inhibited cardiomyocyte proliferation and cardiac regeneration in vitro.
Muscle Cell News
Understanding Spatiotemporal Mechanical Behavior, Viscoelasticity, and Functions of Stem Cell-Derived Cardiomyocytes
[Nanoscale] To probe the time-dependent viscoelastic behaviors of cardiomyocytes with cross-linked polymer networks, the authors measured stem cell-derived cardiomyocyte's deformation, adhesion, and contractility using atomic force microscopy nanoindentation, fluidic micropipette, and digital image correlation.