Publication

[Stem Cells and Development] In the selection of low- and high-density inoculation conditions, scientists found that low-density culture performed better in the final red blood cell product with more cell output and increased average cellular hemoglobin content.

[International Journal of Stem Cells] Researchers investigated the effects of acetaldehyde dehydrogenase 2 (ALDH2) mutations on bone remodeling. They examined the effects of ALDH2 polymorphisms on in vitro osteogensis using hiPSCs.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators generated five different genomic excisions at the C9orf72 locus in a patient-derived iPSC line and a non-diseased wild-type line, and examined gene expression and pathological hallmarks of C9 frontotemporal dementia/ALS in motor neurons differentiated from these lines.

[Cell Death & Disease] The authors demonstrated that a nanocarrier, named The-0504, could cross the blood-brain barrier and specifically deliver the payload to gliomas that express high amounts of the ferritin/transferrin receptor TfR1 (CD71).

[Science Advances] Scientists used proteomics, genetics, and translation assays in cultured cells and mouse brains to reveal altered translation mediated by loss of the kinase TAOK2 in 16p11.2 deletion models.

[Journal Of Neuro-Oncology] Four patient-derived pediatric glioma models were investigated to model rebound growth in vitro based on viable cell counts in response to mitogen-activated protein kinase (MAPK) inhibitor (MAPKi) treatment and withdrawal.