Direct Incorporation of Mesenchymal Stem Cells into a Nanofiber Scaffold – In Vitro and In Vivo Analysis

Stem cells isolated from rat femora were incorporated into poly-l-lactide acid (PLLA) and PLLA-collagen type-I nanofiber scaffolds via simultaneous electrospinning and spraying.
[Scientific Reports]
Schüttler, K. F., Bauhofer, M. W., Ketter, V., Giese, K., Eschbach, D. A., Yenigün, M., Fuchs-Winkelmann, S., & Paletta, J. R. J. (2020). Direct incorporation of mesenchymal stem cells into a Nanofiber scaffold – in vitro and in vivo analysis. Scientific Reports, 10(1), 9557. https://doi.org/10.1038/s41598-020-66281-6 Cite
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Synthesis and Characterization of Silk Ionomers for Layer-By-Layer Electrostatic Deposition on Individual Mammalian Cells

Through the optimization of material properties and composition of incubation buffers, silk ionomers could be electrostatically assembled on the surface of murine fibroblasts and human mesenchymal stem cells to form nanoscale multilayers without significantly impairing cell viability.
[Biomacromolecules]
Synthesis and characterization of silk ionomers for layer-by-layer electrostatic deposition on individual mammalian cells | Biomacromolecules. (n.d.). Retrieved June 15, 2020, from https://pubs.acs.org/doi/10.1021/acs.biomac.0c00523 Cite
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Characterization of a Pluripotent Stem Cell-Derived Matrix with Powerful Osteoregenerative Capabilities

The authors describe a highly osteogenic MSC line generated from induced pluripotent stem cells that generated high yields of an osteogenic cell-matrix in vitro.
[Nature Communications]
McNeill, E. P., Zeitouni, S., Pan, S., Haskell, A., Cesarek, M., Tahan, D., Clough, B. H., Krause, U., Dobson, L. K., Garcia, M., Kung, C., Zhao, Q., Saunders, W. B., Liu, F., Kaunas, R., & Gregory, C. A. (2020). Characterization of a pluripotent stem cell-derived matrix with powerful osteoregenerative capabilities. Nature Communications, 11(1), 3025. https://doi.org/10.1038/s41467-020-16646-2 Cite
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Heat Treatment Dependent Cytotoxicity of Silicalite-1 Films Deposited on Ti-6Al-4V Alloy Evaluated by Bone-Derived Cells

Two types of bone-derived cells were used for a biocompatibility assessment. While no increase in cell membrane damage, in ROS generation and in TNF-alpha secretion of bone-derived cells grown on both silicalite-1 films was found.
[Scientific Reports]
Nemcakova, I., Jirka, I., Doubkova, M., & Bacakova, L. (2020). Heat treatment dependent cytotoxicity of silicalite-1 films deposited on Ti-6Al-4V alloy evaluated by bone-derived cells. Scientific Reports, 10(1), 9456. https://doi.org/10.1038/s41598-020-66228-x Cite
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Canonical Notch Signaling Is Required for Bone Morphogenetic Protein‐Mediated Human Osteoblast Differentiation

Systemic Notch inhibition using diabenzazepine reduced bone morphogenetic protein (BMP)2-induced calvarial bone healing in mice supporting the critical regulatory role of Notch signaling in BMP-induced osteoblastogenesis.
[Stem Cells]
Wagley, Y., Chesi, A., Acevedo, P. K., Lu, S., Wells, A. D., Johnson, M. E., Grant, S. F. A., & Hankenson, K. D. (n.d.). Canonical Notch Signaling is Required for Bone Morphogenetic Protein-mediated Human Osteoblast Differentiation. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3245 Cite
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Bushenhuoxue Formula Accelerates Fracture Healing via Upregulation of TGF-β/Smad2 Signaling in Mesenchymal Progenitor Cells

Researchers performed unilateral open transverse tibial fracture procedure in C57BL/6 mice which were treated with or without Bushenhuoxue formula.
[Phytomedicine]
Hu, S., Ge, Q., Xia, C., Ying, J., Ruan, H., Shi, Z., Xu, R., Xu, T., Lv, S., Fang, L., Zou, Z., Xu, H., Xiao, L., Tong, P., Wang, P., & Jin, H. (2020). Bushenhuoxue formula accelerates fracture healing via upregulation of TGF-β/Smad2 signaling in mesenchymal progenitor cells. Phytomedicine, 76, 153256. https://doi.org/10.1016/j.phymed.2020.153256 Cite
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Fabrication of Stiffness Gradients of GelMA Hydrogels using a 3D Printed Micromixer

A co-culture consisting of human adipose tissue-derived mesenchymal stem cellsand human umbilical cord vein endothelial cells was encapsulated in the gradient construct.
[Macromolecular Bioscience]
Lavrentieva, A., Fleischhammer, T., Enders, A., Pirmahboub, H., Bahnemann, J., & Pepelanova, I. (n.d.). Fabrication of Stiffness Gradients of GelMA Hydrogels Using a 3D Printed Micromixer. Macromolecular Bioscience, n/a(n/a), 2000107. https://doi.org/10.1002/mabi.202000107 Cite
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Bobby Sox Homolog Regulates Tooth Root Formation through Modulation of Dentin Sialophosphoprotein

Investigators generated bobby sox homolog (Bbx) knockout mice to address the functional role of Bbx in tooth formation. During tooth development, Bbx was expressed in both dental epithelium and mesenchyme.
[Journal of Cellular Physiology]
Ihn, H. J., Kim, J. A., Lim, J., Nam, S.-H., Hwang, S. H., Kim, Y. K., Kim, J.-Y., Kim, J.-E., Cho, E.-S., Jiang, R., & Park, E. K. (n.d.). Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.29875 Cite
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Gaucher Disease-Associated Alterations in Mesenchymal Stem Cells Reduce Osteogenesis and Favour Adipogenesis Processes with Concomitant Increased Osteoclastogenesis

Researchers evaluated the process of osteoclastogenesis and observed that conditioned media from Gaucher disease MSCs supernatants induced an increase in the number of osteoclasts.
[Molecular Genetics and Metabolism]
Crivaro, A., Bondar, C., Mucci, J. M., Ormazabal, M., Feldman, R. A., Delpino, M. V., & Rozenfeld, P. A. (2020). Gaucher disease-associated alterations in mesenchymal stem cells reduce osteogenesis and favour adipogenesis processes with concomitant increased osteoclastogenesis. Molecular Genetics and Metabolism. https://doi.org/10.1016/j.ymgme.2020.06.003 Cite
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Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Pre-Conditioned Cardiosphere Derived Cells

Scientists enhanced the effect of cardiosphere-derived cells with APOSEC preconditioning (apoCDC), and investigated the reparative effect in a translational pig model of reperfused MI.
[Molecular Therapy-Methods & Clinical Development]
Winkler, J., Lukovic, D., Mester-Tonczar, J., Zlabinger, K., Gugerell, A., Pavo, N., Jakab, A., Szankai, Z., Traxler, D., Müller, C., Spannbauer, A., Riesenhuber, M., Hasimbegovic, E., Dawkins, J., Zimmermann, M., Ankersmit, H. J., Marbán, E., & Gyöngyösi, M. (2020). Quantitative hybrid cardiac [18F]FDG-PET-MRI images for assessment of cardiac repair by pre-conditioned cardiosphere derived cells. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2020.06.008 Cite
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Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

Intravenous delivery of immunity- and matrix-regulatory cells, derived from human embryonic stem cells, inhibited both pulmonary inflammation and fibrosis in mouse models of lung injury, and significantly improved the survival rate of the recipient mice in a dose-dependent manner, likely through paracrine regulatory mechanisms.
[Cell Research]
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BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

Researchers showed that Bacille-Calmette-Guérin vaccination in healthy human volunteers induced a persistent transcriptional program connected to myeloid cell development and function within the hematopoietic stem and progenitor cell compartment in the bone marrow.
[Cell Host & Microbe]
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