Publication

[Blood] Scientists used a novel mouse model expressing Jak2 V617F under its endogenous promoter at the heterozygous state within a Mpl knock-out background.

[Cancer & Metabolism] Scientists demonstrated that AML cells critically depend on lactate dehydrogenase A (LDHA) to maintain an adequate NAD⁺/NADH balance in support of their abnormal glycolytic activity and biosynthetic demands, which cannot be compensated for by other cellular NAD⁺ recycling systems.

[GSK Plc.] GSK plc and Boston Pharmaceuticals announced that they have entered into an agreement under which GSK will acquire Boston Pharmaceuticals’ lead asset, efimosfermin alfa.

[European Respiratory Journal] Expression and localization of cGAS, cytokines, and type 1 interferons were evaluated in SSc-ILD lung tissues, bronchoalveolar lavage (BAL), and isolated lung fibroblasts.

[Hepatology] Hepatic extracellular matrix protein 1 (ECM1) expression was evaluated and found to be significantly reduced in liver samples from patients with metabolic dysfunction-associated steatohepatitis, and in four established MASH mouse models.

[Cell] Researchers presented an ESC-derived 3D model of the post-gastrulation amnion, post-gastrulation amnioids, that faithfully recapitulates extra-embryonic development up to four weeks post-fertilization, closely mimicking the functional traits of the human amniotic sac.