Publication

[Experimental Cell Research] Functional studies were conducted to investigate its role in lipid uptake and accumulation in human vascular smooth muscle cells using siRNA knockdown and overexpression techniques.

[Apoptosis] Investigators established a cellular model system using a CD19-positive B lineage acute lymphoblastic leukemia (B-ALL) cell line Nalm-6 to investigate the treatment options for CD19-negative relapsed B-ALL after CD19-CAR T cell therapy.

[Cancer Discovery] In preclinical mouse models, YTB323, a novel autologous CD19-directed CAR T-cell therapy expressing the same validated CAR as tisagenlecleucel, exhibited enhanced in vivo expansion and antitumor activity at lower doses than traditionally manufactured CAR T-cells.

[Nature Communications] Lysophosphatidic acid receptor signaling by CD8 T cells promoted tolerogenic states via metabolic reprogramming and potentiating exhaustive-like differentiation to modulate anti-tumor immunity.

[Advanced Science] Hypoimmunogenic iPSCs were generated through CRISPR/Cas9 editing of the human leukocyte antigen molecules in healthy donor-derived iPSCs and differentiated into oligodendrocyte progenitor cells (OPCs_. The OPCs were engrafted into the brains of Canavan disease mice and exhibited widespread distribution in the brain.

[Cancer] Even in the absence of a matched sibling donor, outcomes of allogeneic hematopoietic cell transplantation in second complete remission for acute myeloid leukemia have significantly improved over time, with most favorable outcomes achieved with matched unrelated donors.