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Cardiomyocyte Nuclear Remodeling After Mechanical Unloading

[American Journal Of Physiology-Heart And Circulatory Physiology] Researchers studied whether changes in DNA content with mechanical unloading occurred independent of cardiomyocyte proliferation by comparing human subjects undergoing left ventricular assist device implantation or primary transplantation.

Slo1 Deficiency Impaired Skeletal Muscle Regeneration and Slow-Twitch Fibre Formation

[Journal Of Cachexia Sarcopenia And Muscle] To investigate the involvement of genes in the regulation of muscle dysfunction induced by Slo1 deletion, RNA-seq analysis was performed in primary myoblasts.

Myofibroblast Senescence Promotes Arrhythmogenic Remodeling in the Aged Infarcted Rabbit Heart

[eLife] Researchers investigated the role of senescence in regulating inflammation, fibrosis, and arrhythmogenesis in young and aged infarcted rabbits.

Non-Canonical Telomere Protection Role of FOXO3a of Human Skeletal Muscle Cells Regulated by the TRF2-Redox Axis

[Communications Biology] Scientists showed in transformed fibroblasts and myotubes that the telomere properties of FOXO3a were dependent on the C-terminal segment of its CR2 domain but independent of its Forkhead DNA binding domain and of its CR3 transactivation domain.

miR-136-5p/FZD4 Axis Is Critical for Wnt Signaling-Mediated Myogenesis and Skeletal Muscle Regeneration

[Journal Of Cellular Physiology] Investigators found that miR-136-5p was significantly upregulated during the proliferation and differentiation of C2C12 cells.

Bioinspired PLCL/Elastin Nanofibrous Vascular Tissue Engineering Scaffold Enhances Endothelial Cells and Inhibits Smooth Muscle Cells

[Biomacromolecules] Cell culture experiments showed that a novel composite fiber membrane had high cell viability, promoting the proliferation and adhesion of human umbilical vein endothelial cells and inducing a contractile phenotype in human umbilical artery smooth muscle cells.

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