Non-Canonical Telomere Protection Role of FOXO3a of Human Skeletal Muscle Cells Regulated by the TRF2-Redox Axis

Scientists showed in transformed fibroblasts and myotubes that the telomere properties of FOXO3a were dependent on the C-terminal segment of its CR2 domain but independent of its Forkhead DNA binding domain and of its CR3 transactivation domain.