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Cancer Stem Cell News
TMT-Based Quantitative Proteomic Analysis of Spheroid Cells of Endometrial Cancer Possessing Cancer Stem Cell Properties
[Stem Cell Research & Therapy] Spheroid cells from endometrial cancer cell lines, Ishikawa and HEC1A, exhibited increased colony forming, subsphere forming, chemo-drug resistance, migration, invasion ability, and tumorigenicity, verifying their cancer stem-like cell properties.
Cancer Stem Cell News
Therapeutic Potential of Pentamidine for Glioma-Initiating Cells and Glioma Cells through Multimodal Antitumor Effects
[Cancer Science] Using drug reposition, researchers investigated a therapeutic drug for glioma-initiating cells. Drug screening was undertaken to select candidate agents that inhibit proliferation of two different glioma-initiating cells lines.
Cancer Stem Cell News
Enhanced Binding of β-Catenin and β-TrCP Mediates LMPt’s Anti-CSCs Activity in Colorectal Cancer
[Biochemical Pharmacology] The authors reported a liposome loaded with low toxicity and high effectiveness of miriplatin, lipo-miriplatin with high miriplatin loading, and robust stability, exhibiting a superior inhibitory effect on CSCs and non-CSCs.
Cancer Stem Cell News
m6A-Mediated Upregulation of lncRNA-AC026356.1 Promotes Cancer Stem Cell Maintenance in Lung Adenocarcinoma via Activating Wnt Signaling Pathway
[Aging] Scientists found that lncRNA-AC026356.1 was upregulated in stem spheres and chemo-resistant lung cancer cells. Fish assay also showed that AC026356.1 was predominantly located in the cytoplasm of lung cancer cells and did not have protein-coding potential.
Cancer Stem Cell News
Inorganic Pyrophosphatase 1 Activates the Phosphatidylinositol 3-Kinase/Akt Signaling to Promote Tumorigenicity and Stemness Properties in Colorectal Cancer
[Cellular Signalling] Investigators inspected the functions of inorganic pyrophosphatase 1 (PPA1) in colorectal cancer (CRC). The abundance of PPA1 in CRC tissues was analyzed by utilizing publicly available data from the The Cancer Genome Atlas and Human Protein Atlas project.
Cancer Stem Cell News
ZNF677 Inhibits Oral Squamous Cell Carcinoma Growth and Tumor Stemness by Regulating FOXO3a
[Human Cell] The expression of ZNF677 was analyzed by online database and immunohistochemistry, while the methylation level of ZNF677 was determined by the methylation-specific PCR.