Publication

[Clinical Cancer Research] To determine the role of cytotoxic CD4+ tumor-infiltrating lymphocytes (TILs) in immune checkpoint blockade-resistant tumors, scientists investigated CD4+ TIL-mediated cytotoxicity in matched pairs of TILs and autologous melanoma cell lines, used as a model of patient-specific immune-tumor interaction.

[Cell Reports] Researchers found that receptor editing, a measure of central tolerance, was increased in transitional B cells from common variable immune deficiency (CVID) patients, and that these cells had a higher immunoglobulin κ:λ ratio in CVID patients with autoimmune manifestations than in those with infection only.

[Science Immunology] Upon NK cell attack, gasdermin B (GSDMB)3-expressing cells died by pyroptosis, whereas GSDMB4-expressing cells died by mixed pyroptosis and apoptosis, and GSDMB1/2-expressing cells died only by apoptosis. GSDMB4 partially resisted NK cell-triggered cleavage, suggesting that only GSDMB3 was fully functional.

[Developmental Cell] Researchers reported that polycomb Ezh1 confered quiescence to murine muscle stem cells (MuSCs) through a non-canonical function. In the absence of Ezh1, MuSCs spontaneously exited quiescence.

[Redox Biology] Doing transwell co-culture with bronchial epithelial cells, A549/16-HBE, and human airway smooth muscle cells, researchers found that hemoglobin could protect the smooth muscle soluble guanylyl cyclase from excess nitric oxide.

[Frontiers in Microbiology] The infection models in vitro and in vivo were constructed to explore the pathogenesis of HCMV-related atherosclerosis.