Publication

[Nature Cancer] Scientists reported that induced expression of the secreted protein Gremlin 1 in a mouse model restrained chronic myeloid leukemia (CML) progression and synergized with tyrosine kinase inhibitor treatment, whereas blockade of Gremlin 1 promoted CML development.

[Circulation] Investigators reported evidence that patients with cardiometabolic heart failure with preserved ejection fraction exhibited elevated peripheral blood hematopoietic stem cells.

[Cancer Research] Scientists validated the critical role of the histone methyltransferase SET and MYND domain containing 3 (SMYD3) in the maintenance of leukemia stem cells in chronic myeloid leukemia.

[Haematologica] QuANTUM-First was a randomized Phase III trial in newly diagnosed FLT3-ITDQpositive AML patients treated with quizartinib or placebo plus standard induction and consolidation chemotherapy and/or allogeneic hematopoietic cell transplantation, followed by single-agent maintenance therapy.

[Blood] Through the integration of single-cell multiomics with bulk RNA-Seq and clinical datasets, scientists uncovered a chemotherapy-resistant subpopulation that resembled hematopoietic stem and progenitor cells and was associated with poor clinical outcomes across all subtypes investigated.

[Blood] Researchers comprehensively characterized the expression of immune checkpoint receptors and their ligands in leukemic blasts, T cells, and mesenchymal stromal cells from B-cell acute lymphoblastic leukemia bone marrow (BM) samples at diagnosis and relapse, comparing them with age-matched healthy BM controls.