Publication

[eLife] Scientists showed that mouse Kdm1a deletion caused dramatic reduction of polycomb repressive complex 2 (PRC2) proteins, whereas mouse null mutation of L3mbtl3 or Dcaf5 resulted in PRC2 accumulation and increased H3K27 trimethylation.

[Experimental Hematology] The authors investigated the effects and mechanism of action of azacitidine on three myeloid leukemia associated with Down syndrome cell lines derived from relapsed cases.

[Experimental Hematology] Using primary myeloproliferative neoplasms samples and engineered embryonic stem cells, researchers demonstrated that mutations in JAK2 induce a significant increase in erythroid colony formation, whereas mutations in additional sex combs-like 1 (ASXL1) led to erythroid colony defect.

[Haematologica] The authors investigated the safety and efficacy of belamaf with lenalidomide 25mg on days 1-21 every 28 days and dexamethasone 40mg weekly in transplant ineligible patients with newly diagnosed multiple myeloma.

[Scientific Reports] Scientists used a mouse model with restraint stress to study its effects on plasma lipid metabolites and stenotic vascular remodeling following carotid ligation. In vitro functional and mechanistic studies were performed using macrophages, endothelial cells, and neutrophil cells.

[Advanced Materials] In the laser-induced mouse choroidal neovascularization model, the lutein/nintedanib nanoparticles after a minimally invasive subconjunctival administration could successfully inhibit angiogenesis, chronic inflammation, and scavenge oxidative stress, achieved comparable and even better therapeutic results to that of standard intravitreal injection of anti-VEGF.