Publication

[Cell Host & Microbe] Investigators examined the virological characteristics of the BA.2.86 variant. Their epidemic dynamics modeling suggested that the relative reproduction number of BA.2.86 was significantly higher than that of EG.5.1.

[ACS Nano] Scientists developed a strategy that combines CD44-targeting of activated hepatic stellate cells (HSCs) with an antioxidative approach. They demonstrated that intravenously administered hyaluronic acid–bilirubin nanoparticles effectively targeted the liver, particularly activated HSCs, in fibrotic mice with choline-deficient l-amino acid-defined high-fat diet-induced nonalcoholic steatohepatitis.

[Stem Cell Research & Therapy] Researchers used ROCK inhibitor Y-27632-containing 3T3-CM, MEF-CM, and RbEF-CM to determine the proper feeder-free culture system that could maintain in vitro stem cell morphology of mouse airway basal stem cells.

[Thorax] Investigators delineated the impact of prevalent pollutants such as carbon and zinc oxide nanoparticles, on cellular function and progeny in primary human bronchial epithelial cells from end-stage COPD, early disease,and pulmonary healthy individuals.

[Clinical Cancer Research] The germline mutation USP36 rs3744797 was found to facilitate proliferation, migration, and resistance to EGFR-TKIs via upregulating MLLT3 expression in vitro and in vivo.

[Cancer Cell] Using genomic-wide reduced-representation bisulfite sequencing in two cohorts totaling 179 SCLC patients and using machine learning approaches, the authors reported a highly accurate DNA methylation-based classifier that could distinguish SCLC subtypes.