Publication

[Journal for Immunotherapy of Cancer] This clinical trial evaluated RAPA-201 therapy in combination with fludarabine-sparing low-dose host conditioning for the treatment of patients with relapsed, refractory multiple myeloma.

[Molecular Cancer] Various murine HCC cell lines and myeloid-derived suppressor cells (MDSCs) were used in a series of in vitro and in vivo experiments. Scientists revealed increased infiltration and enhanced function of MDSCs in TME after treatment with sorafenib.

[Nature Communications] The authors demonstrated the efficient generation of blastoids from iPSCs and somatic cell nuclear transfer embryonic stem cells derived from aged monkeys, achieving an 80% formation efficiency.

[Molecular Therapy - Nucleic Acids] The authors demonstrated a gene editing approach that selectively targeted the dominant 3-base pair deletion in the TOR1A DYT1 allele while safeguarding the wild-type TOR1A allele.

[Nature Biotechnology] To predict AAV capsid performance under near-clinical conditions, scientists established side-by-side comparison at single-cell resolution in human livers maintained by normothermic machine perfusion.

[Cell Death & Differentiation] Scientists reported that a small ubiquitin-related modifier (SUMO) modification of p53 was implicated in the process which remarkably increased in Alzheimer's disease patient’s brain.