Publication

[Cell Death Discovery] Using a cerebral organoid model of early human brain development, scientists found that PANX1 was expressed at all stages of organoid development from neural induction through to neuroepithelial expansion and maturation.

[Gut] Researchers explored the precancerous nature of intestinal metaplasia (IM) by analysing epigenetic alterations. Genome-wide DNA methylation analysis was conducted by EPIC BeadArray using IM crypts isolated by Alcian blue staining.

[Biofabrication] Investigators formed embryoid bodies in an ultra-low attachment 384-well plate and subsequently transferred them to the pillar plate containing Matrigel, using a straightforward sandwiching and inverting method.

[Molecular Cancer] The authors established a new potential preclinical model for malignant peritoneal mesothelioma (MPM) using patient-derived MPM organoids and to comprehensively evaluate the practicality of this model in medical research and its feasibility in guiding individualized patient treatment.

[Cell Stem Cell] A single-cell RNA expression atlas of primary and cultured human conjunctiva revealed that keratinocytes expressed multiple antimicrobial peptides and identifies conjunctival tuft cells.

[British Journal Of Cancer] Researchers utilized well-characterized KrasG12D-driven non-small cell lung cancer mouse model to investigate the role of Mediator complex subunit 23 (MED23) in lung cancer.