Publication

[HGG Advances] Scientists developed a procedure including RNA library preparation and a simple pipeline calculating alternative polyadenylation (APA)-shift ratio as a readout for PABPN1 activity. Comparing APA-shift resulted to previously published PAS utilization and APA-shift results, investigators validated this procedure.

[Developmental Cell] Through CD36, fatty acids functioned as both fuels and growth signals to promote muscle stem cell (MUSCs) proliferation. Mechanistically, injury triggered the translocation of CD36 in MuSCs, which relies on dynamic palmitoylation of STX11.

[Circulation] Investigators leveraged an in vivo mosaic knockout system to characterize the role of Carm1, the founding member of protein arginine methyltransferase, in cardiomyocyte maturation.

[Journal Of Cachexia Sarcopenia And Muscle] Researchers used hiPSC-cardiomyocytes from Duchenne muscular dystrophy (DMD) patients selected by Speckle-tracking echocardiography and canine DMD cardiac biopsies to assess key early-stage Duchenne dilated cardiomyopathy features.

[Blood Cancer Journal] Scientists hypothesized that the co-occurrence of CHIP and mCAs at the same locus might have important prognostic implications for malignancy transformation risk.

[Stem Cell Reports] Researchers investigated the effects of thrombopoietin (TPO) and its receptor MPL ablation on marrow and splenic hematopoiesis in TPO−/− and MPL−/− mice during aging.