Publication

[Cell Death & Disease] Researchers found that speckle-type POZ protein (SPOP)n and ELK3 were an interacting partner. The interaction between SPOP and ELK3 resulted in increased ELK3 ubiquitination and destruction, assisted by checkpoint kinase-mediated ELK3 phosphorylation.

[iScience] The authors investigated the mechanisms underlying the toxicity of punicic acid, an isomer of conjugated linolenic acids bearing three conjugated double bonds highly prone to peroxidation, on prostate cancer cells.

[The Prostate] Nucleolar proteomics data and large-scale immunofluorescence were re-analyzed to jointly identify the proteins localized at nucleolus. RNA-Seq data of five prostate cancer (PCa) cohorts were combined and integrated with multi-dimensional data to define the upregulated nucleolar transcription factors in PCa tissues.

[Journal Of Virology] Scientists showed that the action of IFNγ was indirect, as CD4+ T cell-mediated control of type 1 alveolar epithelial cells infection depended on IFNγ receptor expression in CD11c+ cells.

[Nucleic Acids Research] The authors prepared numerous RNA substrates, including both long substrates mimicking the viral genome and short defined RNA, to clarify the substrate preference and cleavage pattern of SARS-CoV-2 nsp15.

[Advanced Materials] Scientists manipulated the immunopotentiator manganese into six differing structures that resemble the architectures of two types of pathogens. They revealed that innate immune cells accurately sense and respond to the architectures, of which two outperformed material candidates showedhigher competence in creating local pro-inflammatory environment with promoted innate immune cell influx and stimulatory effects on multiple subsets of dendritic cells.