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Jawbone-Like Organoids Generated from Human Pluripotent Stem Cells

[Nature Biomedical Engineering] Investigators presented a method for generating jawbone-like organoids from hiPSC through PA1 ectomesenchyme of the mandibular prominence.

Modeling Mesenchymal Stromal Cell Support to Hematopoiesis within a Novel 3D Artificial Marrow Organoid System

[Scientific Reports] The authors reported an original, fully-human in vitro 3D model of the bone marrow microenvironment dedicated to study interactions taking place between mesenchymal stromal cells and hematopoietic stem and progenitor cells during the hematopoietic differentiation.

Patient-Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson-Gilford Progeria Syndrome

[Aging Cell] Scientists established cortical organoids derived from Hutchinson-Gilford progeria syndrome (HGPS) patient-iPSCs from patients with HGPS to investigate the role of progerin in the brain.

Early-Life Exposure to Polypropylene Nanoplastics Induces Neurodevelopmental Toxicity in Mice and Human iPSC-Derived Cerebral Organoids

[Journal of Nanobiotechnology] The authors investigated the impact of maternal exposure to polypropylene nanoplastics on fetal brain development and neurobehavioral outcomes in a mouse model and further explored its mechanism in human cerebral organoids.

Restoration of Striatal Neuroprotective Pathways by Kinase Inhibitor Treatment of Parkinson’S Disease-Linked LRRK2-Mutant Mice

[Science Signaling] Researchers tested the leucine-rich repeat kinase 2 (LRRK2) inhibitor MLi-2 in a mouse model of early stage, LRRK2 mutation–associated Parkinson's disease.

Glial Reactivity Correlates with Synaptic Dysfunction across Aging and Alzheimer’s Disease

[Nature Communications] Scientists investigated the association between glial reactivity and synaptic dysfunction biomarkers in cerebrospinal fluid from 478 individuals in cognitively unimpaired and cognitively impaired individuals.

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