Publication

[Lancet Oncology] The authors investigated the clinical activity and safety of valemetostat in patients with relapsed or refractory peripheral T cell lymphoma, and its safety in patients with relapsed or refractory adult T cell leukemia/lymphoma.

[EMBO Journal] Investigators examined the heterogeneity of human choroid plexus tumors by single-nucleus transcriptome analysis of 23,906 cells from four disease-free choroid plexus and eleven choroid plexus tumors.

[Science Advances] Investigators developed an enhanced cytoplasmic hybrid (cybrid) generation protocol and established isogenic human melanoma cybrid lines with wild-type mitochondrial DNA (mtDNA) or pathogenic mtDNA mutations with partial or complete loss of mitochondrial oxidative function.

[Pharmacology & Therapeutics] The authors review the role of androgen receptor (AR) variants, particularly AR splice variant 7, in CRPC and investigate the latest findings on how natural compounds and their derivatives target AR and AR splice variants.

[Journal of Experimental & Clinical Cancer Research] Scientists addressed the therapeutic effects of a novel anti-Notch1 neutralizing antibody they produced, alone and in combination with immune checkpoint inhibition in melanoma models.

[Cancer Research] While PHGDH amplification explained PHGDH overexpression in a subset of melanomas, oncogenic BRAFV600E also promoted PHGDH transcription through mTORC1-mediated translation of ATF4.