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Sequential Appetite Suppression by Oral and Visceral Feedback to the Brainstem

[Nature] The authors described how prolactin-releasing hormone and GCG neurons, two principal caudal nucleus of the solitary tract cell types that promoted non-aversive satiety, were regulated during ingestion.

Histone Methylation Mediated by NSD1 Is Required for the Establishment and Maintenance of Neuronal Identities

[Cell Reports] Scientists showed that NSD1, the methyltransferase for di-methylated lysine 36 of histone H3, controlled both area and layer identities of the neocortex.

Deriving Early Single-Rosette Brain Organoids from Human Pluripotent Stem Cells

[Stem Cell Reports] Investigators developed a human brain organoid technique that generated self-organizing, single-rosette cortical organoids with reproducible size and structure at early timepoints.

Modular 3D Printed Platform for Fluidically Connected Human Brain Organoid Culture

[Biofabrication] Researchers developed a 3D printing pipeline for the fabrication of tailor-made culturing platforms for fluidically connected but spatially separated brain organoid array culture.

Prenatal Hypertension As the Risk of Eclampsia, HELLP Syndrome, and Critical Obstetric Hemorrhage

[Hypertension Research] The authors clarified the impact of chronic hypertension on obstetric hemorrhage by evaluating a nationwide administrative database in Japan. Women who gave birth between 2018 and 2022 were enrolled.

Human Wharton’s Jelly-Derived Mesenchymal Stromal Cells Promote Bone Formation in Immunodeficient Mice When Administered into a Bone Microenvironment

[Journal Of Translational Medicine] The authors investigated how physiological bone environments affect the osteogenic commitment of recalcitrant MSCs in vitro and in vivo. To this end, MSC of bone marrow and Wharton's jelly origin were co-cultured and induced for synchronous osteogenic differentiation in vitro using transwells.

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