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Hydrophobic Cross-Linked Chains Regulate High Wet Tissue Adhesion Hydrogel with Toughness, Anti-hydration for Dynamic Tissue Repair

[Advanced Materials] Investigators constructed anti-hydration gelatin-acrylic acid-ethylene dimethacrylate hydrogels with hydrophobic cross-linked chains.

Fabrication of Shape-Designable Cartilage from Human Induced Pluripotent Stem Cell-Derived Chondroprogenitors Using a Cell Self-Aggregation Technique

[Biomedical Materials] Scientists described the production of shape-designable cartilage using a novel cell self-aggregation technique and chondroprogenitor cells derived from human induced pluripotent stem cells as the source.

Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension Vasculopathy

[American Journal Of Respiratory And Critical Care Medicine] Investigators quantified immune cells’ proximity and abundance, focusing on those linked to vascular pathology, and evaluated their impact on pulmonary arterial smooth muscle cells and endothelial cells.

Therapeutic Effects of Mesenchymal/Stromal Stem Cells and Their Derived Extracellular Vesicles in Rheumatoid Arthritis

[Stem Cells Translational Medicine] Researchers assessed the effect of human MSCs and MSC-extracellular vesicles on CD4+ T cells from patients with rheumatoid arthritis.

Paired Box 6 Gene Delivery Preserves Beta Cells and Improves Islet Transplantation Efficacy

[EMBO Molecular Medicine] Scientists identified paired box 6 (PAX6) as a critical regulator of beta cell survival. Under diabetic conditions, the human beta cell line EndoC-βH1, db/db mouse, and human islets displayed dampened insulin and incretin signalings and reduced beta cell survival, which were alleviated by PAX6 overexpression.

Notch Signaling Regulates Immunosuppressive Tumor-Associated Macrophage Function in Pancreatic Cancer

[Cancer Immunology Research] Researchers explored the role of Notch signaling, a key regulator of the immune response, within the pancreatic ductal adenocarcinoma microenvironment.

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