Publication

[Nature] The authors showed that AC484 inflamed the tumor microenvironment and promoted natural killer cell and CD8+ T cell function by enhancing JAK–STAT signalling and reducing T cell dysfunction.

[Cell Reports Medicine] Investigators found that loss of Never in mitosis gene A-related kinase 2 (NEK2) in tumor microenvironmental cells was associated with multiple myeloma growth suppression.

[Aging and Disease] Using NEPC-related genome sequencing database analyses, scientists screened RACGAP1, a common differentially expressed gene. They investigated RACGAP1 expression in clinical prostate cancer specimens by IHC.

[European Journal of Pharmaceutics and Biopharmaceutics] Researchers developed a combinatorial nanomedicine comprising abiraterone and enzalutamide bioconjugated survivin-encapsulated gold nanoparticles for targeted therapy of prostate cancer.

[Scientific Reports] Investigators confirmed that pinostilbene directly bound to androgen receptor and inhibited its activation and translocalization. Their results suggested that pinostilbene has the potential to treat enzalutamide-resistant CRPC.

[Scientific Reports] Scientists suggested that editing of miR-379 attenuated the growth-suppressive function of unedited miR-379 in androgen-sensitive prostate cancer cells, thereby promoting tumor growth.