Publication

[Journal Of Clinical Investigation] Investigators demonstrated a novel role of claudin-2 in promoting mucosal healing in inflammatory bowel disease patients and thus regulating vulnerability to colitis severity and colitis-associated cancer, which can be exploited for improved clinical management.

[Nature Protocols] Investigators described a protocol to assemble a complete mouse embryo model using mESCs and induced ESCs to express Cdx2 and Gata4 to reconstitute the epiblast, extraembryonic ectoderm and visceral endoderm lineages, respectively.

[Aging Cell] Using aged iPSC-derived cardiomyocytes, the authors studied the effect of cell age on the young extracellular matrix therapy, an emerging approach for myocardial infarction treatment and prevention.

[Cell Proliferation] Researchers developed a differentiation protocol by mimicking the two-stage development of hepatoblasts, which permited the efficient generation of hepatic progenitor cells from chemically induced iPSCs.

[Philosophical Transactions Of The Royal Society B-Biological Sciences] The authors examined the role of peptidylarginine deiminase IV (PADI4) in maintaining the multi-lineage differentiation potential of mouse ESCs.

[Frontiers In Cell And Developmental Biology] Investigators assessed the ability of 8-cell blastomeres to produce epiblast cells and ESC lines after isolation, and the properties of the resulting lines.