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MYC Is a Regulator of Androgen Receptor Inhibition-Induced Metabolic Requirements in Prostate Cancer

[Cell Reports] Scientists comprehensively characterized the effects of androgen receptor blockade on prostate cancer metabolism using transcriptomics, metabolomics, and bioenergetics approaches.

Loss of PPARγ Activity Characterizes Early Protumorigenic Stromal Reprogramming and Dictates the Therapeutic Window of Opportunity

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators primarily observed CD36 expression in adipocytes and intralobular capillaries within the disease-free breast.

The Phageome in Normal and Inflamed Human Skin

[Science Advances] Using shotgun metagenomics from skin swabs of healthy individuals and patients with atopic dermatitis, scientists found 13,586 potential viral contiguous DNA sequences, which could be combined into 164 putative viral genomes including 133 putative phages.

Inhibition of IL-17 Ameliorates Keratinocyte-Borne Cytokine Responses in an In Vitro Model for House-Dust-Mite Triggered Atopic Dermatitis

[Scientific Reports] Peripheral blood mononuclear cells derived from respectively sensitized atopic dermatitis patients were stimulated with house dust mite extract and cell culture supernatants were applied subsequently in absence or presence of secukinumab to primary human keratinocytes.

Uncovering the Complex Relationship between Balding, Testosterone and Skin Cancers in Men

[Nature Communications] The authors dissected this relationship via Mendelian randomization analyses, using genetic data from recent male-only meta-analyses of cutaneous melanoma and keratinocyte cancers, followed by stratified Mendelian randomization analysis by body-sites.

A Self-Healing Hydrogel Wound Dressing Based on Oxidized Bletilla striata Polysaccharide and Cationic Gelatin for Skin Trauma Treatment

[International Journal Of Biological Macromolecules] The novel hydrogel significantly facilitated wound healing by promoting hair follicles regeneration, blood vessels repair, collagen deposition, and inducing skin tissue remodeling via increased CD31 expression in a full-thickness skin wound rat model.

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