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Extracellular Vesicle-Carried GTF2I from Mesenchymal Stem Cells Promotes the Expression of Tumor-Suppressive FAT1 and Inhibits Stemness Maintenance in Thyroid Carcinoma

[Frontiers Of Medicine] The effects of bone marrow mesenchymal stem cell-derived extracellular vesicles enriched with GTF2I were evaluated on the epithelial–to–mesenchymal transition and stemness maintenance in thyroid carcinoma.

Ubiquitin-Specific Peptidase 5 Facilitates Cancer Stem Cell-Like Properties in Lung Cancer by Deubiquitinating β-Catenin

[Cancer Cell International] Phenotypic effects of ubiquitin-specific peptidase 5 on the CSC-like properties and metastasis were examined by in vitro sphere formation assay, migration assay, invasion assay, and in vivo xenografted animal models.

Clinical Significance of Porphyromonas gingivalis Enriching Cancer Stem Cells by Inhibiting Programmed Cell Death Factor 4 in Esophageal Squamous Cell Carcinoma

[ACS Infectious Diseases] Scientists investigated the functional mechanism by which Porphyromonas gingivalis (Pg) promoted esophageal squamous cell carcinoma (ESCC) chemoresistance and malignancy through inhibiting PDCD4 and enriching CSCs. The effects of Pg and programmed cell death factor 4 on CSCs, chemoresistance, and malignancy of ESCC cells were evaluated by in vitro studies.

Pan Cancer Characterization of Genes Whose Expression Has Been Associated with LINE-1 Antisense Promoter Activity

[Mobile DNA] Hub long interspersed nuclear element-1 (LINE01) antisense promoter-associated genes CENPU and MCM2 showed a correlation with immune infiltration, clinical T stage, and cancer stemness in pan-cancer.

Cancer Stem Cells of Esophageal Adenocarcinoma are Suppressed by Inhibitors of TRPV2 and SLC12A2

[Annals Of Surgical Oncology] Researchers examined the expression profiles of ion transport-related molecules in the CSCs of esophageal adenocarcinoma.

MPZL1 Suppresses the Cancer Stem-Like Properties of Lung Cancer Through β-Catenin/TCF4 Signaling

[Functional & Integrative Genomics] Scientists explored the influence of myelin protein zero-like protein 1 (MPZL1) on the stem-like properties of cancer cells and the underlying mechanism in lung adenocarcinoma.

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