Publication

[Signal Transduction And Targeted Therapy] Scientists explored the efficacy of sorafenib therapy in this population with different concomitant genetic patterns. In a multi-center, cohort study, they enrolled patients with FLT3-ITD AML undergoing allogeneic hematopoietic cell transplantation.

[Advanced Materials] Investigators engineered a novel peptide-drug conjugate-based self-adaptive nanoregulator for mitigating dynamic immune evasion of PDAC.

[Cell Discovery] Researchers identified a previously uncharacterized microprotein, Notch1 degradation-associated regulatory polypeptide (N1DARP), encoded by LINC00261. N1DARP knockout accelerated tumor progression and enhanced stem cell properties in pancreatic cancer organoids and LSL-Kras, LSL-Trp53, and Pdx1-Cre mice.

[Journal Of Clinical Investigation] The authors tested whether replacement of endogenous CDK4 with the inhibitor-resistant mutant CDK4-R24C rescued the loss of β cell mass in IRS2-deficient mice.

[Nature Communications] Targeting the protein subcomplex in pancreatic cancer stem cells with a KMT2A-WDR5 inhibitor attenuated their self-renewal capacity, cell viability, and in vivo tumorigenicity.

[Gut] Scientists investigated sex disparities in clinical outcomes and tumor immune profiles in patients with PDAC who underwent upfront resection or resection preceded by gemcitabine-based neoadjuvant chemoradiotherapy.