Publication

[Experimental Hematology] Researchers analyzed the different phases of regeneration following transplantation. They found that regenerating hematopoietic stem cells initially produced rapidly expanding progenitors and displayed distinct changes in fatty acid metabolism and glycolysis.

[JCI Insight] APTEN-knockdown AML animal model was generated to assess the impact of conditional phosphatases of regenerating liver 2 (PRL2) inhibition on the level of PTEN protein and the development and progression of AML.

[Bone Marrow Transplantation] Researchers compared outcomes, of 1609 patients with secondary AML undergoing HSCT in first complete remission from MUD from 2010 to 2021, receiving or not receiving anti-thymocyte globulin.

[Leukemia & Lymphoma] Investigators conducted a phase I, dose-escalation study of selinexor with mitoxantrone, etoposide, and cytarabine in 23 patients aged < 60 years with relapsed or refractory AML.

[Nature Communications] Researchers uncovered a mechanism of adenosine monophosphate-activated protein kinase expression in the nonalcoholic fatty liver disease to nonalcoholic steatohepatitis transition, which was mediated by a nuclear mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP1)/p38 MAPK-LKB1 axis that promoted hepatocyte death.

[Nature Communications] Scientists integrated single-cell transcriptome, single-nuclei chromatin accessibility, and cell-type specific 3D genome profiles from human islets and identified type II diabetes-associated β-cell heterogeneity at both transcriptomic and epigenomic levels.