Publication

[Blood] To find alternative ways to target Notch signals, researchers investigated Cell division cycle 73 (Cdc73), which is a Notch cofactor and key component of the RNA polymerase-associated transcriptional machinery, an emerging target in T cell acute lymphoblastic leukemia.

[Journal Of Experimental Medicine] Scientists hypothesized that bone marrow–derived cells with heterozygous loss-of-function mutations of DNMT3A, the most common genetic alteration in clonal hematopoiesis, contributed to the pathogenesis of colon cancer.

[Autophagy] Researchers addressed why autophagy depletion led to a drastic loss of the stem cell compartment. Using inducible deletion of autophagy specifically in adult HSCs and in mice chimeric for autophagy-deficient and normal HSCs, they demonstrated that the stem cell loss is cell-intrinsic.

[Leukemia] Investigators exploited patient-derived xenograft models with B cell acute lymphoblastic leukemia (B-ALL) cells transduced with a miR-126 reporter allowing the prospective isolation of miR-126(high) cells for their functional and transcriptional characterization.

[European Journal Of Haematology] In this retrospective analysis, researchers compared the safety and efficacy of peripheral stem cell mobilization with a G-CSF intensified mobilization regimen in sickle cell trait donors with a conventional G-CSF mobilization regimen in healthy donors.

[Journal Of Hematology & Oncology] This first-in-human, open-label, single-arm, multicenter trial included AML patients in complete remission with persisting or increasing measurable residual disease and evaluated safety/tolerability, pharmacokinetics and preliminary efficacy of FLYSYN at different dose levels administered intravenously.