Review

[Nature Reviews Gastroenterology & Hepatology] The authors provide an up-to-date perspective on the natural history of nonalcoholic fatty liver disease (NAFLD), emphasizing the reversible nature of the disease, summarizing possible mechanisms underlying recompensation in NAFLD, discussing challenges that need to be addressed and outlining future research directions in the field.

[Haematologica] The authors provide a summary of what is known in the field, challenges in the management of Down syndrome patients with leukemia, and key questions in the field.

[Nature Reviews Endocrinology] The authors provide a comprehensive overview of the evolving functions of the vasculature in regulating adipose tissue biology in health and obesity.

[Nature Reviews Immunology] The authors address the importance of muscular activity for maintaining a healthy immune system and discuss the effects of a single bout of exercise, and those of ‘regular’ exercise on anticancer immunity, including tumor infiltrates.

[Immunity] Investigators reviewed CAR T cell design and the mechanisms that drive sustained CAR T cell effector activity and anti-tumor function. They discuss engineering approaches aimed at improving anti-tumor function through a variety of mechanistic interventions for both hematologic and solid tumors.

[Journal Of Translational Medicine] Scientists highlight the intricate strategies employed by CSCs to evade immune surveillance and develop resistance to therapies. They examine the dynamic interplay between CSCs and the TME, shedding light on how this interaction impacts cancer progression.