Review

[Heliyon] The authors hypothesize that incorporation of healthy donor allogeneic Tregs may provide more lucid and beneficial results.

[Nature Reviews Endocrinology] Investigators map the progress in cell replacement therapies for type 1 diabetes mellitus and outline the remaining challenges and future directions.

[Nature Reviews Molecular Cell Biology] The authors discuss novel insights into the compositional diversity of matrisome components and the mechanisms that lead to tissue-specific assemblies and architectures tailored to support specific functions.

[Brain] The authors review how 3D brain organoids have been used to investigate various neurodevelopmental disorders and their pathophysiology, including Fragile X syndrome, Rett syndrome, Angelman syndrome, microlissencephaly, Prader-Willi syndrome, Timothy Syndrome, and tuberous sclerosis syndrome.

[Nature Reviews Cancer] Scientists provide an overview of vascular targeting approaches and puts them into context based on subsequent improved understanding of the tumor vasculature as an integral part of the tunor microenvironment with which it is functionally interlinked.

[Nature Reviews Nephrology] Modulating hyaluronan (HA) matrix functions by targeting its binding partners holds promise as a therapeutic strategy for restoring tissue homeostasis and mitigating pathological processes. Further research in this area is warranted to enable the development of novel therapeutic approaches for kidney and other diseases characterized by dysregulated HA metabolism.