Review

[Advanced Science] Investigators present the latest CRISPR-Cas9 technology achievements and prospect to translational medicine advances.

[MedComm] The authors introduce different design strategies of CAR-T cell delivery hydrogels and discuss various types of therapeutic agents incorporated in the hydrogel platforms and diverse hydrogel formulations.

[Toxicological Research] The authors summarize the role of sphingosine kinase in the course of liver disease and illustrate its effects on both physiological and pathological conditions of the liver.

[Stem Cell Reviews and Reports] The authors focus on novel technical challenges in intestinal stem cell (ISC) fate drawing upon recent research with the goals of clarifying our understanding of complex ISCs, elucidating the integrated intestinal crypt niche, and creating new opportunities for therapeutic development.

[Trends In Molecular Medicine] Investigators unveil a functional role of a human germline mutation found in the ribonuclease Z enzyme, ELAC2, in prostate cancer.

[Nature Reviews Immunology] Understanding the imprinting of Treg cell identity and specialized function will be key to unravelling basic mechanisms of autoimmunity and identifying novel targets for drug development.