Review

[Cell Stem Cell] The authors provide an overview of the achievements and challenges in using hPSC-derived organoids to conduct relevant high-throughput, high-contentscreens and drug evaluation.

[Cancer Medicine] Several issues, that is, high cost, toxicity, allergic reactions, less efficacy, multidrug resistance, and the economic cost of conventional anti-cancer therapies, has prompted scientists to discover innovative approaches and new chemo-preventive agents.

[Clinical Epigenetics] Investigators focus on DNA hydroxymethylation and its epigenetic regulators in human and mouse placental development and function.

[Macromolecular Rapid Communications] Investigators describe the preparation and design requirements of nanocomposite hydrogels and discusses their applications and challenges in regenerative medicine, hoping to clarify the relationship between the two.

[Journal Of Cellular Physiology] The authors highlight the crosstalk between hepatic stellate cells and other hepatic cells in orchestrating acute hepatic injury and discuss how findings from recent studies provide insights into potential therapeutic approaches.

[Investigational New Drugs] Investigators summarize the latest research progress of liquid biopsy based on blood cell-free DNA in early screening of HCC.