Review

[Signal Transduction and Targeted Therapy] The authors give an overview of the history of patient-derived xenograft (PDX) models and the process of PDX model establishment, highlighting its strenghts and weaknesses.

[Stem Cells Translational Medicine] The authors focus on lineage transcription factor-mediated direct reprogramming and describe the conversion process along with the underlying epigenetic mechanisms, as well as other potential induction strategies to generate induced keratinocyte stem cells, and challenges associated with in situ reprogramming for skin repair.

[Journal Of Cell Communication And Signaling] Scientists review how dermal aging involves a feed‐forward process that reinforces the aged dermal fibroblast phenotype and promotes age‐related dermal extracellulat matrix deterioration, and disccuss the expression of the aged dermal fibroblast phenotype involves both adaptive and cell‐autonomous mechanisms.

[Pathology - Research and Practice] Small nucleolar RNA host gene 8 (SNHG8) is a long non-coding RNA (lncRNA) that has physiological roles in epithelial and muscle satellite cells. This lncRNA has been reported to be over-expressed in a variety of cancer cell lines.

[Trends In Cancer] The authors summarize the role of Stearoyl coenzyme A desaturase-1 (SCD) in cancer cell progression, survival, and ferroptosis and discuss potential strategies to exploit SCD1 inhibition in future clinical trials.

[Heliyon] Investigators summarize the beneficial effects of fruit phytoconstituents on NAFLD based on epidemiological, clinical and experimental evidence, focusing especially on their mechanisms of action.