Review

[Life Sciences] Investigators describe characteristics and isolation methods of MSC-EVs, and focus on their therapeutic potential describing its roles in tissue repair, anti-fibrosis, and cancer with an emphasis on the molecular mechanism and immune modulation and clinical trials.

[Critical Reviews In Oncology/Hematology] Scientists summarize the targeting of CSCs by various immunotherapy strategies such as monoclonal antibodies, tumor vaccines, immune checkpoint inhibitors, and chimeric antigen receptor-T cells in pre-clinical and clinical studies.

[American Journal Of Physiology-Cell Physiology] Investigators synthesize current literature to provide an overview of the mechanoregulatory role of fibronectin-mediated cell migration.

[Science Signaling] Scientists summarize the causes and consequences of fibrous stroma and how this stromal cue is transmitted to the nuclei of parenchymal cells through a physical continuum from the ECM to chromatin, as well as ECM-dependent biochemical signaling that contributes to cellular transformation.

[Journal of Translational Medicine] Scientists analyze the physiology and pathology of neural development starting from the available in vitro and in vivo models and highlight the current knowledge concerning key mitochondrial pathways involved in this process.

[Signal Transduction And Targeted Therapy] Investigators retrace the history of relevant research on metabolic memory and summarize its salient characteristics. They provide a detailed discussion of the mechanisms by which metabolic memory may be involved in disease development at molecular, cellular, and organ levels, with emphasis on the impact of epigenetic modulations.