Review

[Experimental & Molecular Medicine] The authors examine the molecular mechanisms regulating the cell cycle, current clinical applications of cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors in breast cancer, and key mechanisms contributing to drug resistance.

[Journal of Investigative Dermatology] Metabolic pathways, together with receptor- and nonreceptor-mediated phenotypic activities of its intermediates, have been identified as a cutaneous melatoninergic system. Pharmacological modulation of melatonin or its metabolites may be used to treat cutaneous disorders and aging.

[Stem Cell Research & Therapy] The authors summarize the connection between mitochondrial dysfunction and hair follicle development, outline the links between diseases related to mitochondrial disorders and hair issues, and highlight the influence of mitochondrial dysfunction on androgenetic alopecia.

[BioDrugs] The authors review the role of TL1A in inflammatory bowel disease, evaluate the efficacy of anti-TL1A therapies in clinical trials, and discuss future directions for research and treatment.

[Signal Transduction and Targeted Therapy] The authors provide a comprehensive review of cellular signaling pathways, their therapeutic potential, and the development of more effective therapeutics for HCC.

[Molecular Therapy] Scientists provide background on the history and potential therapeutic value of mesenchymal stromal/stem cells (MSC), an overview of MSC products with regulatory approval, and a summary of registered MSC trials.