Publication

[Nucleic Acids Research] SOX2, SOX17, and SOX17FNV were all able to bind nucleosome core particles in vitro, which is a prerequisite for pioneer transcription factors.

[Life Science Alliance] Investigators used the in vitro differentiation of human pluripotent stem cells into cardiomyocytes to study the role of c-JUN. The knockout of c-JUN improved cardiomyocyte generation, as determined by the number of TNNT2+ cells.

[Tissue Engineering And Regenerative Medicine] The Arginine-Glycine-Aspartate motif was incorporated into a recombinant elastin-like peptide (REP). hESCs were treated with REP containing RGD motif during suspension and cryopreservation, and the survival rate was analyzed.

[Nature Communications] Scientists presented the single-cell transcriptomic landscape of synchronously resected pancreatic ductal adenocarcinoma primary tumors and matched liver metastases. They performed comparative analysis on both cellular composition and functional phenotype between primary and metastatic tumors.

[Scientific Reports] Human bone marrow-derived mesenchymal stem cells were seeded on the surfaces of hydroxyapatite-based scaffolds and cultured for 21 days in three different conditions: static 3D culture, 3D culture in a perfusion bioreactor, and dynamic 3D culture in a rotating bioreactor.

[Nature Communications] Researchers found that high-mobility group box 1 (Hmgb1), normally upregulated with injury and involved in adult cerebrovascular repair, was highly expressed in astrocytes at birth and then decreased rapidly.