Publication

[Advanced Science] 26 increased peptides were identified in skin tissues of frogs (Pelophylax nigromaculatus) exposed to electron beams, among which four promoted the wound healing of irradiated skin in rats.

[Journal Of Investigative Dermatology] Scientists constructed a mouse model of specific ASH2L deletion in epidermal progenitor cells and investigated its effect on the development of mouse epidermal lineage. Deletion of ASH2L in epidermal progenitor cells caused thinning of the suprabasal layer of the epidermis and delayed hair follicle morphogenesis in newborn mice.

[British Journal Of Cancer] The authors investigated the effect of trastuzumab monotherapy and its combination with different HER2 targeting treatments in a panel of breast cancer cell lines and patient-derived organoids using biochemical methods and cell viability assays.

[EMBO Reports] Scientists reported a sensitivity of the mRNA splicing machinery to phosphorylation changes in response to LB-100 in colorectal adenocarcinoma.

[Annals Of The New York Academy Of Sciences] Scientists explored the role of claudin-7 in regulating colonic intestinal stem cell function. In 3D colonoid culture, claudin-7–deficient crypts were unable to survive and form spheroids. Inhibition of the Hippo pathway or activation of Notch signaling partially rescued the defective stem cell behavior.

[PLOS One] Scientists constructed patient-derived organoids derived from pancreatic tumor organoid libraries. Each pancreatic organoid demonstrated varied niche factor dependencies, providing an avenue for targeted therapy, supported through growth analysis following combinatory treatment of Wnt inhibitor and standard chemotherapy in vitro.