Publication

[Cancer Research] Development of a Pten-null lung squamous carcinoma mouse model revealed that tumors with PTEN loss were refractory to anti-PD-1, highly metastatic and fibrotic, and secreted TGF-β/CXCL10 to promote conversion of CD4+ lymphocytes into regulatory T cells.

[Cell Death & Disease] Scientists reported that LINC00641 was down-regulated in tumor tissues and its downregulation was associated with poor outcomes in lung adenocarcinoma. LINC00641 was localized primarily in the nucleus and was modified by m6A.

[Cell Death Discovery] Researchers explored the role of hepatoma-derived growth factor (HDGF) in gefitinib resistance in NSCLC and discovered the underlying mechanisms. Stable HDGF knockout or overexpression cell lines were generated to perform experiments in vitro and in vivo.

[Nature] Researchers showed that agonists of α2-adrenergic receptors had very strong anti-tumor activity when used as monotherapies in multiple immunocompetent tumour models.

[Nature Immunology] Investigators explored drivers of fibroblast-like synoviocyte heterogeneity in inflamed joints of patients with rheumatoid arthritis using paired single-cell RNA and ATAC sequencing, multiplexed imaging and spatial transcriptomics.

[Nature Communications] The authors showed comprehensive phenotyping in samples of circulating and tumor-resident B cells as well as serum antibodies in melanoma patients.