Publication

[Food Science & Nutrition] Researchers evaluated the effects of green tea extract on suppression of cellular proliferation through testing the expression of miR-34a in PC3 prostate cancer cells.

[World Journal of Clinical Oncology] Scientists hypothesized the BM-targeting alpha-emitter radium-223 dichloride (Ra223) could target subclinical bone disease and delay progression.

[Brain] Researchers employed high-dimensional mass cytometry, single-cell RNA-sequencing, ex vivo T cell secretome analysis, and antigen presentation assays to achieve a comprehensive characterization of adaptive immune cell populations.

[Cancer Research] Scientists showed that delivery of only four synthetic guide RNAs with Cas9 endonuclease efficiently induced simultaneous DNA double-strand breaks, resulting in efficient cell death in a cell-type-specific manner.

[JAMA Oncology] Investigators suggested that given both treatment-related harms and benefits, immune checkpoint inhibitor (ICI) + chemotherapy use in the first SACT setting requires informed decision-making; the potential benefits of ICI + chemotherapy vs single ICI in high-risk subgroups is encouraging.

[Cancer Immunology Research] The authors identified cell interactions that predicted progression including increased frequency of CD8⁺ exhausted T cells and stromal cells and decreased frequency of CD56bright NK cells and plasmacytoid dendritic cells.