Publication

[Cancer Cell] Researchers utilized single-cell RNA sequencing to investigate the dynamics of immune and stromal cells in 19 patients with mismatch repair-deficient and microsatellite instability-high colorectal cancers who received neoadjuvant PD-1 blockade.

[Scientific Reports] Among the immune cells, maternal PD1+ CD8 T cell subsets were less abundant in term laboring compared to term non-laboring women.

[Nature Medicine] Investigators reported updated interim results from the first-in-human phase I evaluation of autologous natural killer T cells (NKTs) co-expressing a GD2-specific chimeric antigen receptors (CAR) with interleukin 15 in 12 children with neuroblastoma.

[Nature Neuroscience] Researchers showed that melanin-concentrating hormone (MCH) downregulated synaptic transmission, modulated firing rate homeostasis in hippocampal neurons, and reversed the increased excitatory drive to CA1 neurons in AppNL-G-F mice.

[Nature Cancer] Investigators showed that mitochondria transfer is a prevalent phenomenon in glioblastoma (GBM). They identified horizontal mitochondria transfer from astrocytes as a mechanism that enhances tumorigenesis in GBM.

[Nature Communications] Scientists established the clinical utility of serial circulating tumor DNA sampling to track response and progression and discover acquired resistance mechanisms that can be leveraged to develop therapeutic strategies to overcome lorlatinib resistance.