Publication

[Nature Communications] Integrative transcriptomic and preclinical studies unraveled that p140Cap controlled an epistatic axis where, through the upstream inhibition of β-Catenin, it restricted tumorigenicity and self-renewal of tumor-initiating cells.

[Cancer Research] Researchers performed spatial transcriptomic and single-cell analyses of the mouse and human glioblastomas (GBM) microenvironment to dissect the impact of distinct anatomical regions of brains on GBM.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Using stable isotope-resolved metabolomics analysis, the authors showed that the epithelial mesenchymal transition was associated with profound changes in metabolites, including elevation of cytoplasmic succinate levels.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators reported a prodrug, Nic-A that was designed to target triple-negative breast cancer (TNBC) CSCs and was found to inhibit both proliferating TNBC cells and CSCs via signal transducer and transcriptional activator 3 dysregulation and suppression of CSC-like properties.

[Cell Death Discovery] Investigators explored the Notch4 function in triple-negative breast cancer (TNBC). They found that silencing Notch4 enhanced tumorigenic ability in TNBC cells via upregulating Nanog expression, a pluripotency factor of embryonic stem cells.

[Cancer Cell International] Taking advantage from a pan Fibroblast Growth Factor (FGF)-trap molecule, the authors singled out and analyzed a Uveal Melanoma-Cancer stem-like cell subset with marked stem-like properties.