Publication

[Developmental Cell] The authors presented a single-cell transcriptome-wide view of the cynomolgus macaque placenta throughout gestation.

[Cancer Research] To discover alternative treatments to transcriptionally active ESR1 gene fusions (ESR1-TAF), a mass spectrometry-based kinase inhibitor pulldown assay was deployed to identify druggable kinases that are upregulated by diverse ESR1-TAFs.

[Cancer Research] To identify oncogenic RNA-binding proteins in TNBC, researchers employed an in vivo CRISPR screen and a TNBC progression model, which revealed small nuclear ribonucleoprotein polypeptide C (SNRPC) as a key modulator of TNBC progression.

[Cell Death & Disease] Scientists investigated the biological role and clinical applications of proline rich 15 (PRR15) on TNBC. PRR15 gene was differentially expressed between TNBC and non-TNBC patients, previously described as an oncogenic factor in breast cancer.

[International Journal of Cancer] Investigators examined in vitro> reciprocal effect between breast cancer cells and cancer-sensitized peripheral primary sensory neurons. Secretome obtained from either cultured DRG neurons from tumor-burdened rats, or MRMT1 breast cancer cells were used to study neuronal and cancer cell reciprocity.

[Frontiers in Cell and Developmental Biology] Researchers showed that CD146 negatively regulated transendothelial migration in breast cancer. This inhibitory activity was reflected by a reduction in melanoma cell adhesion molecule (MCAM) gene expression and increased promoter methylation in tumor tissue compared to normal breast tissue.