FOS Licenses Early Events in Stem Cell Activation Driving Skeletal Muscle Regeneration

Investigators identified a prominent FBJ osteosarcoma oncogene mRNA and protein signature in recently activated satellite cells that was rapidly, heterogeneously, and transiently induced by muscle damage.
[Cell Reports]
Almada, A. E., Horwitz, N., Price, F. D., Gonzalez, A. E., Ko, M., Bolukbasi, O. V., Messemer, K. A., Chen, S., Sinha, M., Rubin, L. L., & Wagers, A. J. (2021). FOS licenses early events in stem cell activation driving skeletal muscle regeneration. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108656 Cite
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A Constant Pool of Lgr5+ Intestinal Stem Cells Is Required for Intestinal Homeostasis

Using a Lgr5-2A-DTR model, which ablates Lgr5+ cells with near-complete efficiency and retains endogenous levels of Lgr5 expression, researchers showed that persistent depletion of Lgr5+ intestinal stem cells in fact compromised small intestinal epithelial integrity and reduced epithelial turnover in vivo.
[Cell Reports]
Tan, S. H., Phuah, P., Tan, L. T., Yada, S., Goh, J., Tomaz, L. B., Chua, M., Wong, E., Lee, B., & Barker, N. (2021). A constant pool of Lgr5+ intestinal stem cells is required for intestinal homeostasis. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108633 Cite
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Circular RNA FLNA Acts as a Sponge of miR-486-3p in Promoting Lung Cancer Progression via Regulating XRCC1 and CYP1A1

Investigators found that miR-486-3p was low-expressed in lung cancer. miR-486-3p, which has been found to target XRCC1 and CYP1A1, was regulated by circFLNA. CircFLNA was located in the cytoplasm and had a high expression in lung cancer cells.
[Cancer Gene Therapy]
Pan, J., Huang, G., Yin, Z., Cai, X., Gong, E., Li, Y., Xu, C., Ye, Z., Cao, Z., & Cheng, W. (2021). Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1. Cancer Gene Therapy, 1–21. https://doi.org/10.1038/s41417-021-00293-w Cite
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MKL1-Induced lncRNA SNHG18 Drives the Growth and Metastasis of Non-Small Cell Lung Cancer via the miR-211-5p/BRD4 Axis

Researchers employed lncRNA array technology to identify differentially expressed lncRNAs in non-small cell lung cancer cells with or without overexpression of megakaryocytic leukemia 1.
[Cell Death & Disease]
Fan, H., Yuan, J., Li, Y., Jia, Y., Li, J., Wang, X., & Li, X. (2021). MKL1-induced lncRNA SNHG18 drives the growth and metastasis of non-small cell lung cancer via the miR-211-5p/BRD4 axis. Cell Death & Disease, 12(1), 1–15. https://doi.org/10.1038/s41419-021-03399-z Cite
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Application of Green Tea Catechins, Polysaccharides, and Flavonol Prevent Fine Dust Induced Bronchial Damage by Modulating Inflammation and Airway Cilia

While searching for an anti-fine dust particle (FDP) reagent, scientists found that green tea extract and fractions rich in flavonol glycosides and crude tea polysaccharides had protective effects against FDP-stimulated cellular damage in the BEAS-2B airway epithelial cell line.
[Scientific Reports]
Kim, J., Choi, H., Choi, D.-H., Park, K., Kim, H.-J., & Park, M. (2021). Application of green tea catechins, polysaccharides, and flavonol prevent fine dust induced bronchial damage by modulating inflammation and airway cilia. Scientific Reports, 11(1), 2232. https://doi.org/10.1038/s41598-021-81989-9 Cite
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Hypoxic Tumor-Derived Exosomal Circular RNA SETDB1 Promotes Invasive Growth and EMT via the miR-7–Sp1 Axis in Lung Adenocarcinoma

The authors discovered that exosomes obtained from hypoxic lung adenocarcinoma cells improved the migration, invasion and proliferation capacity of normoxic lung adenocarcinoma cells.
[Molecular Therapy-Nucleic Acids]
Xu, L., Liao, W.-L., Lu, Q.-J., Zhang, P., Zhu, J., & Jiang, G.-N. (2021). Hypoxic tumor-derived exosomal circular RNA SETDB1 promotes invasive growth and EMT via the miR-7–Sp1 axis in lung adenocarcinoma. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.01.019 Cite
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Three-Dimensional Interactions between Enhancers and Promoters during Intestinal Differentiation Depend upon HNF4

Researchers applied chromosome conformation capture combined with chromatin immunoprecipitation and sequencing to measure enhancer-promoter interactions in progenitor and differentiated cells of the intestinal epithelium.
[Cell Reports]
Chen, L., Cao, W., Aita, R., Aldea, D., Flores, J., Gao, N., Bonder, E. M., Ellison, C. E., & Verzi, M. P. (2021). Three-dimensional interactions between enhancers and promoters during intestinal differentiation depend upon HNF4. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108679 Cite
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A Genome-Scale CRISPR Screen Reveals Factors Regulating Wnt-Dependent Renewal of Mouse Gastric Epithelial Cells

Scientists investigated the in vivo role of Dhx15 in intestinal antibacterial responses by generating mice that were intestinal epithelial cell-specific deficient for Dhx15.
[Proceedings of the National Academy of Sciences of the United States of America]
Murakami, K., Terakado, Y., Saito, K., Jomen, Y., Takeda, H., Oshima, M., & Barker, N. (2021). A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells. Proceedings of the National Academy of Sciences, 118(4). https://doi.org/10.1073/pnas.2016806118 Cite
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Inflammation-Driven Deaminase Deregulation Fuels Human Pre-Leukemia Stem Cell Evolution

Comparative whole-genome and whole-transcriptome sequencing analyses of FACS-purified pre-leukemia stem cells from myeloproliferative neoplasm patients reveal APOBEC3C upregulation, an increased C-to-T mutational burden, and hematopoietic stem and progenitor cell proliferation during progression, which can be recapitulated by lentiviral APOBEC3C overexpression.
[Cell Reports]
Jiang, Q., Isquith, J., Ladel, L., Mark, A., Holm, F., Mason, C., He, Y., Mondala, P., Oliver, I., Pham, J., Ma, W., Reynoso, E., Ali, S., Morris, I. J., Diep, R., Nasamran, C., Xu, G., Sasik, R., Rosenthal, S. B., … Jamieson, C. (2021). Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108670 Cite
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Metoclopramide Treatment Blocks CD93-Signaling-Mediated Self-Renewal of Chronic Myeloid Leukemia Stem Cells

The authors identified CD93 as an important regulator of self-renewal and proliferation of murine and human leukemia stem cells, but not hematopoietic stem cells.
[Cell Reports]
Riether, C., Radpour, R., Kallen, N. M., Bürgin, D. T., Bachmann, C., Schürch, C. M., Lüthi, U., Arambasic, M., Hoppe, S., Albers, C. E., Baerlocher, G. M., & Ochsenbein, A. F. (2021). Metoclopramide treatment blocks CD93-signaling-mediated self-renewal of chronic myeloid leukemia stem cells. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108663 Cite
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Conserved Regulatory Logic at Accessible and Inaccessible Chromatin during the Acute Inflammatory Response in Mammals

Investigators report the identification of a set of NF-κB-bound elements and common chromatin landscapes underlying the acute inflammatory response across cell-types and mammalian species.
[Nature Communications]
Alizada, A., Khyzha, N., Wang, L., Antounians, L., Chen, X., Khor, M., Liang, M., Rathnakumar, K., Weirauch, M. T., Medina-Rivera, A., Fish, J. E., & Wilson, M. D. (2021). Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals. Nature Communications, 12(1), 567. https://doi.org/10.1038/s41467-020-20765-1 Cite
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