Aberrant CREB1 Activation in Prostate Cancer Disrupts Normal Prostate Luminal Cell Differentiation

Researchers discovered that CREB1 played a central role in maintaining new luminal cell survival and that oncogenesis dramatically changed the CREB1-induced transcriptome. CREB1 was active in luminal cells, but not basal cells.
[Oncogene]
Watson, M. J., Berger, P. L., Banerjee, K., Frank, S. B., Tang, L., Ganguly, S. S., Hostetter, G., Winn, M., & Miranti, C. K. (2021). Aberrant CREB1 activation in prostate cancer disrupts normal prostate luminal cell differentiation. Oncogene, 1–13. https://doi.org/10.1038/s41388-021-01772-y Cite
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Myofibril and Mitochondria Morphogenesis Are Coordinated By a Mechanical Feedback Mechanism in Muscle

The authors manipulated mitochondrial dynamics and found that increased mitochondrial fusion during myofibril assembly prevented mitochondrial intercalation in flight muscles.
[Nature Communications]
Avellaneda, J., Rodier, C., Daian, F., Brouilly, N., Rival, T., Luis, N. M., & Schnorrer, F. (2021). Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle. Nature Communications, 12(1), 2091. https://doi.org/10.1038/s41467-021-22058-7 Cite
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CGRP Protects Bladder Smooth Muscle Cells Stimulated By High Glucose through Inhibiting p38 MAPK Pathway In Vitro

Researchers indicated that calcitonin gene-related peptide (CGRP) protected bladder smooth muscle cells from oxidative stress induced by high glucose in vitro, and inhibit the α-SM-actin expression decrease through inhibiting the intracellular p38 MAPK signaling pathway.
[Scientific Reports]
Xue, J., Liu, Y., Zhang, S., Ding, L., Shen, B., Shao, Y., & Wei, Z. (2021). CGRP protects bladder smooth muscle cells stimulated by high glucose through inhibiting p38 MAPK pathway in vitro. Scientific Reports, 11(1), 7643. https://doi.org/10.1038/s41598-021-87140-y Cite
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Vascular Smooth Muscle-Derived Trpv1+ Progenitors Are a Source of Cold-Induced Thermogenic Adipocytes

Scientists identified transient receptor potential cation channel subfamily V member 1 (Trpv1)+ vascular smooth muscle cells as previously unidentified thermogenic adipocyte progenitors.
[Nature Metabolism]
Shamsi, F., Piper, M., Ho, L.-L., Huang, T. L., Gupta, A., Streets, A., Lynes, M. D., & Tseng, Y.-H. (2021). Vascular smooth muscle-derived Trpv1 + progenitors are a source of cold-induced thermogenic adipocytes. Nature Metabolism, 1–11. https://doi.org/10.1038/s42255-021-00373-z Cite
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Physiological and Pharmacological Stimulation for In Vitro Maturation of Substrate Metabolism in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Researchers investigated substrate metabolism in hiPSC-CMs grown as a monolayer and in 3D, in porous collagen-derived scaffolds and in engineered heart tissue, by measuring rates of glycolysis and glucose and fatty acid oxidation, and changes in gene expression and mitochondrial oxygen consumption.
[Scientific Reports]
Lopez, C. A., Al-Siddiqi, H. H. A. A., Purnama, U., Iftekhar, S., Bruyneel, A. A. N., Kerr, M., Nazir, R., da Luz Sousa Fialho, M., Malandraki-Miller, S., Alonaizan, R., Kermani, F., Heather, L. C., Czernuszka, J., & Carr, C. A. (2021). Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes. Scientific Reports, 11(1), 7802. https://doi.org/10.1038/s41598-021-87186-y Cite
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Bioengineered In Vitro 3D Model of Myotonic Dystrophy Type 1 Human Skeletal Muscle

Biofabrication tools can be applied to engineer human three-dimensional culture systems that complement current preclinical research models. Investigators described the development of the first in vitro three-dimensional model of myotonic dystrophy type 1 human skeletal muscle.
[Biofabrication]
Fernández-Garibay, X., Ortega, M. A., Cerro-Herreros, E., Comelles, J., Martínez, E., Artero, R., Fernandez-Costa, J. M., & Ramon, J. (2021). Bioengineered in vitro 3D model of myotonic dystrophy type 1 human skeletal muscle. Biofabrication. https://doi.org/10.1088/1758-5090/abf6ae Cite
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MicroRNA-129-5p Inhibited C2C12 Myogenesis and Repressed Slow Fiber Gene Expression In Vitro

Researchers revealed miR-129-5p as a negative regulator of myogenic differentiation and slow fiber gene expression, affecting body metabolic homeostasis.
[American Journal of Physiology-Cell Physiology]
Peng, Y., Xu, M., Dou, M., Shi, X., Yang, G., & Li, X. (2021). MicroRNA-129-5p Inhibited C2C12 Myogenesis and Repressed Slow Fiber Gene Expression in vitro. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00578.2020 Cite
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CircHIPK3 Regulates the Autophagy and Apoptosis of Hypoxia/Reoxygenation-Stimulated Cardiomyocytes via the miR-20b-5p/ATG7 axis

The authors examined the regulatory effect of circular RNA HIPK3 (circHIPK3) during myocardial ischemia/reperfusion and investigated its mechanism in cardiomyocyte autophagy and apoptosis.
[Cell Death Discovery]
Qiu, Z., Wang, Y., Liu, W., Li, C., Zhao, R., Long, X., Rong, J., Deng, W., Shen, C., Yuan, J., Chen, W., & Shi, B. (2021). CircHIPK3 regulates the autophagy and apoptosis of hypoxia/reoxygenation-stimulated cardiomyocytes via the miR-20b-5p/ATG7 axis. Cell Death Discovery, 7(1), 1–12. https://doi.org/10.1038/s41420-021-00448-6 Cite
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LncRNA-FKBP1C Regulates Muscle Fiber Type Switching By Affecting the Stability of MYH1B

Investigators demonstrated that long non-coding RNA(lncRNA)-FKBP1C could bound with MYH1B and enhance its protein stability, thus affecting proliferation, differentiation of myoblasts and conversion of skeletal muscle fiber types.
[Cell Death Discovery]
Yu, J., Wang, Z., Yang, X., Ma, M., Li, Z., & Nie, Q. (2021). LncRNA-FKBP1C regulates muscle fiber type switching by affecting the stability of MYH1B. Cell Death Discovery, 7(1), 1–12. https://doi.org/10.1038/s41420-021-00463-7 Cite
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Long-Term Effects of Human Induced Pluripotent Stem Cell-Derived Retinal Cell Transplantation in Pde6b Knockout Rats

Scientists evaluated the long-term effects of human induced pluripotent stem cell-derived retinal pigment epithelial and photoreceptor cell transplantation in Pde6b knockout rats to study retinitis pigmentosa.
[Experimental & Molecular Medicine]
Yang, J. M., Chung, S., Yun, K., Kim, B., So, S., Kang, S., Kang, E., & Lee, J. Y. (2021). Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-021-00588-w Cite
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Clinical Application of a Lung Cancer Organoid (Tumoroid) Culture System

Using airway organoid media developed by the Clevers laboratory, scientists succeeded in generating three lung tumoroid lines for long-term culture from 41 lung cancer cases.
[npj Precision Oncology]
Yokota, E., Iwai, M., Yukawa, T., Yoshida, M., Naomoto, Y., Haisa, M., Monobe, Y., Takigawa, N., Guo, M., Maeda, Y., Fukazawa, T., & Yamatsuji, T. (2021). Clinical application of a lung cancer organoid (tumoroid) culture system. Npj Precision Oncology, 5(1), 1–12. https://doi.org/10.1038/s41698-021-00166-3 Cite
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