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Divergent FOXA1 Mutations Drive Prostate Tumorigenesis and Therapy-Resistant Cellular Plasticity
[Science] Investigators established FOXA1 as a multifaceted oncogene, with distinct mutational classes divergently evolving to drive prostate tumorigenesis or therapy-resistant progression.
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Innate Immunity and the NF-κB Pathway Control Prostate Stem Cell Plasticity, Reprogramming, and Tumor Initiation
[Nature Cancer] Researchers showed that Pten deletion in basal cells led to distinct cell fate reprogramming and tumor initiation in a regionalized manner.
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Isoform-Specific Function of NSD3 in DNA Replication Stress Confers Resistance to PARP Inhibitors in Prostate Cancer
[Molecular Cell] Scientists demonstrated that dysregulated ubiquitination and turnover by the cullin 3ZBTB2 E3 ligase complex induce the upregulation of the short isoform of nuclear-receptor-binding SET domain protein 3, which confers PARPi resistance in prostate cancer cells and patient-derivedmetastatic castration-resistant prostate cancer samples.
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PruEV-AI: A Simple Approach Combines Urinary Extracellular Vesicle Isolation With AI-Assisted Analysis for Prostate Cancer Diagnosis
[Small Methods] Scientists introduced PruEV-AI, an integrated diagnostic system that combines rapid urinary extracellular vesicles isolation with AI-based biomarker analysis.
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Spatial Metabolomics Informs the Use of Clinical Imaging for Improved Detection of Cribriform Prostate Cancer
[Proceedings of the National Academy of Sciences of the United States of America] Investigators supported the feasibility of using clinical metabolic imaging techniques as adjunctive tools for improving cribriform prostate cancer detection in clinical practice, with prospective studies in larger cohorts warranted to obtain definitive results.
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Fine Structural Design of 3βHSD1 Inhibitors for Prostate Cancer Therapy
[Proceedings of the National Academy of Sciences of the United States of America] Scientists demonstrated the feasibility of using predicted structural models for optimizing lead compounds, and HEAL-116 provides a promising avenue for the clinical validation of 3βHSD1 inhibitors in prostate cancer therapy.