Publication

[Nature Communications] Researchers introduced an optimized method that employs mammalian target of rapamycin (mTOR) signaling inhibition in embryonic epicardium, inducing a quiescent state that enhances multi-step epicardial maturation.

[Nature Communications] By integrating multi-omics data across ESC states, scientists identified super-enhancers (SE) interacting with master transcription factors, exemplified by the Klf5-adjacent SE (K5aSE). K5aSE deletion impaired proliferation, differentiation, and Klf5 expression, partially rescued by KLF5 reintroduction.

[Nature Communications] Researchers showed with male mice that hepatic glutamate accumulates in vesicles of perivenous hepatocytes through vesicular glutamate transporter 3 (VGLUT3), regulated by the aryl hydrocarbon receptor upon chronic alcohol intake.

[Nature Communications] Investigators conducted the Phase II LIVERTI trial testing domvanalimab, a monoclonal Fc-silent anti-TIGIT antibody, plus zimberelimab, an anti-PD-1 antibody, in immunotherapy refractory HCC.

[Science Advances] As demonstrated in a rabbit orthotopic liver cancer model, artery infusion of magnesium microsphere–dispersed lipiodol offered greatly enhanced therapeutic outcome compared to lipiodol-based or polymeric-bead–based transarterial chemoembolization.

[Nature Communications] Researchers showed that BMP signaling regulates the survival of the small intestine epithelial cells by inhibiting integrin expression and thereby inducing cell apoptosis.