Publication

[Advanced Materials] To effectively inhibit aerobic glycolysis, increase drug delivery efficiency, and improve drug sensitivity, researchers successfully designed and prepared a novel TMZ nanocapsule for the combined delivery of siPKM2 and TMZ.

[Cancer Research] Researchers identified a circRNA derived from MYBL1 pre-mRNA that accompanied overexpression of MYBL1 in adenoid cystic carcinoma (ACC). Overexpression of circMYBL1 was correlated with increased lung metastasis and poor overall survival in ACC patients.

[Cancer Research] To provide insights into the molecular mechanisms regulating IL1A expression in PDAC, researchers performed transcriptional profiling of The Cancer Genome Atlas datasets and pharmacologic screening in PDAC cells and identified p38α MAPK as a key positive regulator of IL1A expression.

[Molecular Psychiatry] Scientists replicated the altered corticogenesis in the Huntington's disease (HD) fetal brain using HD patient-derived human cortical organoids (hCOs). Our HD-hCOs had pathological phenotypes, including deficient junctional complexes in the neural tubes, delayed postmitotic neuronal maturation, dysregulated fate specification of cortical neuron subtypes, and abnormalities in early HD subcortical projections during corticogenesis.

[Cell Death & Disease] Investigators revealed that Cldn-7 deletion disrupts the self-renewal and differentiation of colonic stem cells alongside the formation of colonic organoids in vitro. Additionally, these Cldn-7 knockout models exhibited heightened susceptibility to experimental colitis, limited epithelial repair and regeneration, and increased differentiation toward the secretory lineage.

[Signal Transduction And Targeted Therapy] Researchers utilized islet organoids derived from human embryonic stem cells, animal models, and COVID-19 patients to discover that fibroblast growth factor 7 (FGF7) enhanced ACE2 expression within the islets, facilitating SARS-CoV-2 infection and resulting in impaired insulin secretion.