Investigators identified a prominent FBJ osteosarcoma oncogene mRNA and protein signature in recently activated satellite cells that was rapidly, heterogeneously, and transiently induced by muscle damage.
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Almada, A. E., Horwitz, N., Price, F. D., Gonzalez, A. E., Ko, M., Bolukbasi, O. V., Messemer, K. A., Chen, S., Sinha, M., Rubin, L. L., & Wagers, A. J. (2021). FOS licenses early events in stem cell activation driving skeletal muscle regeneration. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108656 Cite
Using a Lgr5-2A-DTR model, which ablates Lgr5+ cells with near-complete efficiency and retains endogenous levels of Lgr5 expression, researchers showed that persistent depletion of Lgr5+ intestinal stem cells in fact compromised small intestinal epithelial integrity and reduced epithelial turnover in vivo.
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Investigators found that miR-486-3p was low-expressed in lung cancer. miR-486-3p, which has been found to target XRCC1 and CYP1A1, was regulated by circFLNA. CircFLNA was located in the cytoplasm and had a high expression in lung cancer cells.
[Cancer Gene Therapy]
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Researchers employed lncRNA array technology to identify differentially expressed lncRNAs in non-small cell lung cancer cells with or without overexpression of megakaryocytic leukemia 1.
[Cell Death & Disease]
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While searching for an anti-fine dust particle (FDP) reagent, scientists found that green tea extract and fractions rich in flavonol glycosides and crude tea polysaccharides had protective effects against FDP-stimulated cellular damage in the BEAS-2B airway epithelial cell line.
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Kim, J., Choi, H., Choi, D.-H., Park, K., Kim, H.-J., & Park, M. (2021). Application of green tea catechins, polysaccharides, and flavonol prevent fine dust induced bronchial damage by modulating inflammation and airway cilia. Scientific Reports, 11(1), 2232. https://doi.org/10.1038/s41598-021-81989-9 Cite
The authors discovered that exosomes obtained from hypoxic lung adenocarcinoma cells improved the migration, invasion and proliferation capacity of normoxic lung adenocarcinoma cells.
[Molecular Therapy-Nucleic Acids]
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Researchers applied chromosome conformation capture combined with chromatin immunoprecipitation and sequencing to measure enhancer-promoter interactions in progenitor and differentiated cells of the intestinal epithelium.
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Chen, L., Cao, W., Aita, R., Aldea, D., Flores, J., Gao, N., Bonder, E. M., Ellison, C. E., & Verzi, M. P. (2021). Three-dimensional interactions between enhancers and promoters during intestinal differentiation depend upon HNF4. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108679 Cite
Scientists investigated the in vivo role of Dhx15 in intestinal antibacterial responses by generating mice that were intestinal epithelial cell-specific deficient for Dhx15.
[Proceedings of the National Academy of Sciences of the United States of America]
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Murakami, K., Terakado, Y., Saito, K., Jomen, Y., Takeda, H., Oshima, M., & Barker, N. (2021). A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells. Proceedings of the National Academy of Sciences, 118(4). https://doi.org/10.1073/pnas.2016806118 Cite
Comparative whole-genome and whole-transcriptome sequencing analyses of FACS-purified pre-leukemia stem cells from myeloproliferative neoplasm patients reveal APOBEC3C upregulation, an increased C-to-T mutational burden, and hematopoietic stem and progenitor cell proliferation during progression, which can be recapitulated by lentiviral APOBEC3C overexpression.
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Jiang, Q., Isquith, J., Ladel, L., Mark, A., Holm, F., Mason, C., He, Y., Mondala, P., Oliver, I., Pham, J., Ma, W., Reynoso, E., Ali, S., Morris, I. J., Diep, R., Nasamran, C., Xu, G., Sasik, R., Rosenthal, S. B., … Jamieson, C. (2021). Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108670 Cite
The authors identified CD93 as an important regulator of self-renewal and proliferation of murine and human leukemia stem cells, but not hematopoietic stem cells.
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Riether, C., Radpour, R., Kallen, N. M., Bürgin, D. T., Bachmann, C., Schürch, C. M., Lüthi, U., Arambasic, M., Hoppe, S., Albers, C. E., Baerlocher, G. M., & Ochsenbein, A. F. (2021). Metoclopramide treatment blocks CD93-signaling-mediated self-renewal of chronic myeloid leukemia stem cells. Cell Reports, 34(4). https://doi.org/10.1016/j.celrep.2020.108663 Cite
Investigators report the identification of a set of NF-κB-bound elements and common chromatin landscapes underlying the acute inflammatory response across cell-types and mammalian species.
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Alizada, A., Khyzha, N., Wang, L., Antounians, L., Chen, X., Khor, M., Liang, M., Rathnakumar, K., Weirauch, M. T., Medina-Rivera, A., Fish, J. E., & Wilson, M. D. (2021). Conserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals. Nature Communications, 12(1), 567. https://doi.org/10.1038/s41467-020-20765-1 Cite