Researchers discovered that CREB1 played a central role in maintaining new luminal cell survival and that oncogenesis dramatically changed the CREB1-induced transcriptome. CREB1 was active in luminal cells, but not basal cells.
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The authors manipulated mitochondrial dynamics and found that increased mitochondrial fusion during myofibril assembly prevented mitochondrial intercalation in flight muscles.
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Researchers indicated that calcitonin gene-related peptide (CGRP) protected bladder smooth muscle cells from oxidative stress induced by high glucose in vitro, and inhibit the α-SM-actin expression decrease through inhibiting the intracellular p38 MAPK signaling pathway.
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Scientists identified transient receptor potential cation channel subfamily V member 1 (Trpv1)+ vascular smooth muscle cells as previously unidentified thermogenic adipocyte progenitors.
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Researchers investigated substrate metabolism in hiPSC-CMs grown as a monolayer and in 3D, in porous collagen-derived scaffolds and in engineered heart tissue, by measuring rates of glycolysis and glucose and fatty acid oxidation, and changes in gene expression and mitochondrial oxygen consumption.
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Lopez, C. A., Al-Siddiqi, H. H. A. A., Purnama, U., Iftekhar, S., Bruyneel, A. A. N., Kerr, M., Nazir, R., da Luz Sousa Fialho, M., Malandraki-Miller, S., Alonaizan, R., Kermani, F., Heather, L. C., Czernuszka, J., & Carr, C. A. (2021). Physiological and pharmacological stimulation for in vitro maturation of substrate metabolism in human induced pluripotent stem cell-derived cardiomyocytes. Scientific Reports, 11(1), 7802. https://doi.org/10.1038/s41598-021-87186-y Cite
Biofabrication tools can be applied to engineer human three-dimensional culture systems that complement current preclinical research models. Investigators described the development of the first in vitro three-dimensional model of myotonic dystrophy type 1 human skeletal muscle.
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Researchers revealed miR-129-5p as a negative regulator of myogenic differentiation and slow fiber gene expression, affecting body metabolic homeostasis.
[American Journal of Physiology-Cell Physiology]
The authors examined the regulatory effect of circular RNA HIPK3 (circHIPK3) during myocardial ischemia/reperfusion and investigated its mechanism in cardiomyocyte autophagy and apoptosis.
[Cell Death Discovery]
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Qiu, Z., Wang, Y., Liu, W., Li, C., Zhao, R., Long, X., Rong, J., Deng, W., Shen, C., Yuan, J., Chen, W., & Shi, B. (2021). CircHIPK3 regulates the autophagy and apoptosis of hypoxia/reoxygenation-stimulated cardiomyocytes via the miR-20b-5p/ATG7 axis. Cell Death Discovery, 7(1), 1–12. https://doi.org/10.1038/s41420-021-00448-6 Cite
Investigators demonstrated that long non-coding RNA(lncRNA)-FKBP1C could bound with MYH1B and enhance its protein stability, thus affecting proliferation, differentiation of myoblasts and conversion of skeletal muscle fiber types.
[Cell Death Discovery]
Scientists evaluated the long-term effects of human induced pluripotent stem cell-derived retinal pigment epithelial and photoreceptor cell transplantation in Pde6b knockout rats to study retinitis pigmentosa.
[Experimental & Molecular Medicine]
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Using airway organoid media developed by the Clevers laboratory, scientists succeeded in generating three lung tumoroid lines for long-term culture from 41 lung cancer cases.
[npj Precision Oncology]
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Yokota, E., Iwai, M., Yukawa, T., Yoshida, M., Naomoto, Y., Haisa, M., Monobe, Y., Takigawa, N., Guo, M., Maeda, Y., Fukazawa, T., & Yamatsuji, T. (2021). Clinical application of a lung cancer organoid (tumoroid) culture system. Npj Precision Oncology, 5(1), 1–12. https://doi.org/10.1038/s41698-021-00166-3 Cite