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Generation of Mature Epicardium Derived from Human-Induced Pluripotent Stem Cells via Inhibition of mTOR Signaling

[Nature Communications] Researchers introduced an optimized method that employs mammalian target of rapamycin (mTOR) signaling inhibition in embryonic epicardium, inducing a quiescent state that enhances multi-step epicardial maturation.

Klf5-Adjacent Super-Enhancer Functions As a 3D Genome Structure-Dependent Transcriptional Driver to Safeguard ESC Identity

[Nature Communications] By integrating multi-omics data across ESC states, scientists identified super-enhancers (SE) interacting with master transcription factors, exemplified by the Klf5-adjacent SE (K5aSE). K5aSE deletion impaired proliferation, differentiation, and Klf5 expression, partially rescued by KLF5 reintroduction.

Binge Drinking Triggers VGLUT3-Mediated Glutamate Secretion and Subsequent Hepatic Inflammation by Activating mGluR5/NOX2 in Kupffer Cells

[Nature Communications] Researchers showed with male mice that hepatic glutamate accumulates in vesicles of perivenous hepatocytes through vesicular glutamate transporter 3 (VGLUT3), regulated by the aryl hydrocarbon receptor upon chronic alcohol intake.

Dual TIGIT and PD-1 Blockade with Domvanalimab Plus Zimberelimab in Hepatocellular Carcinoma Refractory to Anti-PD-1 Therapies: The Phase II LIVERTI Trial

[Nature Communications] Investigators conducted the Phase II LIVERTI trial testing domvanalimab, a monoclonal Fc-silent anti-TIGIT antibody, plus zimberelimab, an anti-PD-1 antibody, in immunotherapy refractory HCC.

Magnesium Microspheres for Enhanced Transarterial Chemoembolization Therapy of Hepatocellular Carcinoma: From Animal Models to a Pilot Clinical Study

[Science Advances] As demonstrated in a rabbit orthotopic liver cancer model, artery infusion of magnesium microsphere–dispersed lipiodol offered greatly enhanced therapeutic outcome compared to lipiodol-based or polymeric-bead–based transarterial chemoembolization.

Positional BMP Signaling Orchestrates Villus Length in the Small Intestine

[Nature Communications] Researchers showed that BMP signaling regulates the survival of the small intestine epithelial cells by inhibiting integrin expression and thereby inducing cell apoptosis.

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