Publication

[Acta Biochimica Et Biophysica Sinica] Researchers investigated the positive effects of MSCs against ferroptosis in an acute liver failure model and explore the underlying molecular mechanisms of their therapeutic function.

[Journal Of Controlled Release] Scientists isolated platelet-rich plasma-derived exosomes, which contained abundant bioactive molecules, and investigated their potential to increase the regenerative capacity of MSCs.

[Stem Cells] The administration of umbilical cord-MSCs in rats led to a progressive amelioration of chronic obstructive pulmonary disease, as demonstrated by enhanced lung function and reduced inflammatory response.

[ESC Heart Failure] Designated adenoviral preprotrypsin-leading sequence apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) was used to overexpress secretory APE1/Ref-1 and assess its role in preventing doxorubicin-induced cardiomyopathy in vitro.

[Nature Communications] Investigators studied a unique prospective cohort of vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) patients. They showed that monocytes from VEXAS are quantitatively and qualitatively impaired and display features of exhaustion with aberrant expression of chemokine receptors.

[Cancer Immunology Research] Scientists identified a novel immunotherapeutic target, immunoglobulin superfamily member 1 (IGSF1), by proteome analysis, a membrane glycoprotein proposed to regulate thyroid function.