Publication

[Cell Reports Medicine] Researchers discovered that EMSY, inducing a BRCAness phenotype, was preferentially expressed in breast CSCs, promoted ALDH+ cells enrichment, and was positively correlated with poor relapse-free survival.

[Genome Research] Investigators explored the causal relationship between oxidative stress, somatic mutations in pre-tumor-initiated normal tissues, and tumor incidence in the small intestines of MUTYH-proficient and MUTYH-deficient mice.

[Cellular And Molecular Life Sciences] Scientists described a novel peptide ligand that recognizes CD13 with high affinity and selectivity. Biochemical studies showed that most CD13 molecules expressed on the surface of ECs are catalytically inactive.

[Translational Psychiatry] To model the neuropathology of schizophrenia (SCZ) during early critical periods of brain development, we utilized patient-derived induced pluripotent stem cells to generate 3D cerebral organoids and define cell-specific signatures of disease. when compared to controls, differential gene expression analysis revealed significant enrichment in genes that function in vessel formation, vascular regulation, and inflammatory response in SCZ endothelial cells.

[Cell Cycle] Researchers explored the effects of exogenous supplement of high-density lipoprotein on vascular endothelial cells in a uremia-mimic environment.

[Tissue Engineering Part A] Investigators induced the formation of fenestrae in nonfenestrated hiPSCs-derived endothelial cells (hiPSC-ECs). VEGFA and phorbol myristate acetate were used as inducers of fenestrae in hiPSC-ECs.