Publication

[Scientific Reports] A prospective observational multicenter study including pregnant women with a positive RT-PCR or a positive serology for SARS-CoV-2 and compatible symptoms, from April to December 2020, in 11 French maternities

[Nature Communications] By analyzing dynamic changes in transcriptome and enhancer profile during human trophoblast stem cell to extravillous trophoblast differentiation, researchers defined stage-specific regulators, including an early-stage transcription factor, TFAP2C, and multiple late-stage transcription factors.

[Science Advances] Mechanistically, monoamine oxidase B (MAOB) induced a reactive stroma with activated marker expression, increased extracellular matrix remodeling, and acquisition of a protumorigenic phenotype through enhanced production of reactive oxygen species.

[Biophysical Journal] Investigators built an in silico model combining Alphafold2 (AF2) and all-atom molecular dynamics to understand and predict an optimal hinge amino acid sequence length for a given single-chain variable fragment (scFv) targeting a specific cancer antigen.

[Cell Reports Medicine] Researchers reported that allogeneic transplantation of genetically engineered, primary, hypoimmune, pseudo-islets resulted in their engraftment into a fully immunocompetent, diabetic non-human primate wherein they provide stable endocrine function and enable insulin independence without inducing any detectable immune response in the absence of immunosuppression.

[Cell Death & Disease] Investigators identified BRPF reader proteins, along with several epigenetic groups that acted as targets effectively reversing the resistance mediated by ABCB1.