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Hesperetin Promotes Diabetic Wound Healing by Inhibiting Ferroptosis Through the Activation of SIRT3

[Phytotherapy Research] Scientists investigated the potential molecular mechanisms through which hesperetin reduced ferroptosis in human umbilical vein endothelial cells and promoted angiogenesis and wound healing.

THBS1 Promotes Angiogenesis and Accelerates ESCC Malignant Progression by the HIF-1/VEGF Signaling Pathway

[Cell Biology International] Researchers studied the specific role of THBS1 in esophageal squamous cell carcinoma (ESCC) and its molecular mechanism. Tube formation of human umbilical vein endothelial cells in vitro was decreased when cultured with conditioned medium from THBS1-silenced cells.

Placenta-Derived Mesenchymal Stem Cells Protect Against Diabetic Kidney Disease by Upregulating Autophagy-Mediated SIRT1/FOXO1 Pathway

[Renal Failure] Scientists explored the renoprotective effect of placenta-derived MSCs and the potential mechanism of SIRT1/FOXO1 pathway-mediated autophagy in diabetic kidney disease.

Tumor-Derived Small Extracellular Vesicles Facilitate Omental Metastasis of Ovarian Cancer by Triggering Activation of Mesenchymal Stem Cells

[Cell Communication And Signaling] The impact of extracellular vesicles and miR-320a-activated adipose-derived mesenchymal stem cells on tumor growth and metastasis was assessed in subcutaneous and orthotopic ovarian cancer xenograft mouse models.

Nanoparticle-Based DNA Vaccine Protects Against SARS-CoV-2 Variants in Female Preclinical Models

[Nature Communications] Investigators developed lipid nanoparticles to provide safe and effective delivery of plasmid DNA and showed protection against variants of concerns in female small animal models.

Targeted mRNA Nanoparticles Ameliorate Blood–Brain Barrier Disruption Postischemic Stroke by Modulating Microglia Polarization

[ACS Nano] In a transient middle cerebral artery occlusion (MCAO) mouse model of an ischemic stroke, researchers demonstrated that intravenously injected mIL-10@MLNPs induce IL-10 production and enhance the M2 polarization of microglia.

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