Resveratrol inhibited the migration and invasion of prostate cancer cells, promoted the demethylation of tissue inhibitor of metalloproteinases (TIMP)2 and TIMP3 to upregulate their expressions, and suppressed the expressions of MMP2 and MMP9.
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Resveratrol inhibits the tumor migration and invasion by upregulating TET1 and reducing TIMP2/3 methylation in prostate carcinoma cells - Wang - - The Prostate - Wiley Online Library. (n.d.). Retrieved June 19, 2020, from https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.24029 Cite
Scientists showed that their homemade engrailed-2 (EN2) monoclonal antibody could specifically bind endogenous and exogenous EN2 protein in three different prostate cancer cell lines.
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Li, Q., Shi, Y., Sa, R., Hao, J., Hu, J., Xiao, M., Wang, C., Yan, L., Qiao, B., & Chen, G. (2020). Altered staining patterns and expression level of Engrailed-2 in benign prostatic hyperplasia and prostate Cancer predict prostatic disease progression. BMC Cancer, 20(1), 555. https://doi.org/10.1186/s12885-020-07049-z Cite
Researchers investigated the target genes of miR-1908 by siRNA screening and identified that spermidine synthase was the key regulator of extracellular vesicle secretion in 22Rv1 cells.
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Researchers discovered a promising selectivity of both alkaloids for human prostate cancer cells, including highly drug-resistant lines, compared to non-malignant cells.
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Dyshlovoy, S. A., Kudryashova, E. K., Kaune, M., Makarieva, T. N., Shubina, L. K., Busenbender, T., Denisenko, V. A., Popov, R. S., Hauschild, J., Fedorov, S. N., Bokemeyer, C., Graefen, M., Stonik, V. A., & von Amsberg, G. (2020). Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting. Scientific Reports, 10(1), 9764. https://doi.org/10.1038/s41598-020-66428-5 Cite
In vitro validations confirmed that androgen receptor and ETS-related gene (ERG) regulated a subset of TPCATs, most notably for EPCART.
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Kohvakka, A., Sattari, M., Shcherban, A., Annala, M., Urbanucci, A., Kesseli, J., Tammela, T. L. J., Kivinummi, K., Latonen, L., Nykter, M., & Visakorpi, T. (2020). AR and ERG drive the expression of prostate cancer specific long noncoding RNAs. Oncogene, 1–11. https://doi.org/10.1038/s41388-020-1365-6 Cite
Scientists knocked down KLF5 in prostate cancer cells and found that KLF5 knockdown promoted invasive ability of prostate cancer cells in vitro and in vivo .
[Cell Death & Disease]
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Ma, J.-B., Bai, J.-Y., Zhang, H.-B., Jia, J., Shi, Q., Yang, C., Wang, X., He, D., & Guo, P. (2020). KLF5 inhibits STAT3 activity and tumor metastasis in prostate cancer by suppressing IGF1 transcription cooperatively with HDAC1. Cell Death & Disease, 11(6), 1–14. https://doi.org/10.1038/s41419-020-2671-1 Cite
The authors found that suppression of isoprenylcysteine carboxylmethyltransferase resulted in reduced self-renewal/stemness in KRAS-driven pancreatic and breast cancer cells.
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Scientists report that a positive modulator of canonical WNT signaling pathway, RSPO-LGR4, upregulates key self-renewal genes and is essential for leukemia stem cell self-renewal in a subset of acute myeloid leukemia.
[Cell Stem Cell]
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Researchers showed that S100A6 regulated intracellular and mitochondria calcium buffering of HSC upon cytokine stimulation and have demonstrated that Akt activator SC79 reverted the levels of intracellular and mitochondrial calcium in HSC.
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The authors isolated a mouse strain with a single missense mutation, MlklD139V, that altered the two-helix ‘brace’ that connects the killer four-helix bundle and regulatory pseudokinase domains.
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Scientists analyzed the expression and clinical significance of Y-box binding protein 1 and markers of autophagy in NSCLC and examined their roles in regulating sensitivity to cisplatin in NSCLC.
[Cell Death & Disease]
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