Publication

[EMBO Journal] A comprehensive single-cell transcriptome sequencing was applied to profile rat models of toxin-induced liver tumorigenesis and HCC patients.

[Cell Death Discovery] Researchers showed that methyltransferase-like proteins 9 (METTL9) expression was elevated in HCC, and its high expression was associated with poor survival outcomes. Knockdown of METTL9 observed a significant inhibition of HCC cell viability, migration, and invasion both in vitro and in vivo.

[Nature Aging] Using complementary genetic approaches, investigators demonstrated that continuous induction of the reprogramming factors in vivo leads to hepatic and intestinal dysfunction resulting in decreased body weight and contributing to premature death.

[Scientific Data] Investigators performed a proteomics meta-analysis of public data to refine the plasma extracellular vesicles (EV) composition by separating EV proteins and contaminants into different clusters.

[Scientific Reports] Researchers explored a dual impact of pressure, and volume overload due to aortocaval fistula on Cx43 and extracellular matrix as well as the effect of renin–angiotensin blockade.

[ACS Biomaterials Science & Engineering] Scientists proposed an innovative method based on magneto-mechanical actuation to induce endothelial permeability. This method employed FDA-approved PEGylated superparamagnetic iron oxide nanoparticles and alternating nonheating magnetic fields.