The Treatment with Trandolapril and Losartan Attenuates Pressure and Volume Overload Alternations of Cardiac Connexin-43 and Extracellular Matrix in Ren-2 Transgenic Rats

Researchers explored a dual impact of pressure, and volume overload due to aortocaval fistula on Cx43 and extracellular matrix as well as the effect of renin–angiotensin blockade.