Publication

[Naunyn-Schmiedebergs Archives Of Pharmacology] Ramelteon partially abrogated TGF-β1-induced pulmonary fibrosis and reduced fibroblast proliferation, extracellular matrix deposition, and differentiation into myofibroblasts. In vivo experiments, ramelteon attenuated bleomycin-induced pulmonary fibrosis and collagen deposition.

[Food & Function] Scientists reported that in LX-2 HSCs, ergothioneine upregulated the expression of Hint1 and Smad7 and suppressed their activation provoked by TGFβ1.

[Oncogene] The authors identified key deubiquitinases that significantly impact breast cancer progression and have important implications for breast cancer therapeutics.

[Journal of Translational Medicine] Researchers demonstrated that the expression of Sine oculis homeobox homolog 1 (SIX1) varied among different subtypes of breast cancer and that it upregulated breast cancer grading and lymph node metastasis.

[Breast Cancer Research] Scientists highlighted patatin-like phospholipase domain-containing lipase 8 (PNPLA8) as key regulator of phospholipid metabolic reprogramming and malignant phenotypes in TNBC.

[Nanomedicine] Investigators synthesized the gold nanoparticles (GNPs) using a dual extract of tulsi and Vinca for breast cancer tumor regression. The GNPs were synthesized and characterized for their microscopic, spectroscopic, and crystalline properties.